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Laboratoire Bio-PeroxIL - EA 7270





  • Di Cara F, Savary S, Kovacs WL, Kim P, Rachubinski RA - The peroxisome: an up-and-coming organelle in immunometabolism . Trends Cell Biol. 2022 Jul 1;S0962-8924(22)00140-4. doi: 10.1016/ j.tcb.2022.06.001. PMID: 35788297 DOI: 10.1016/j.tcb.2022.06.001 - IF 20.808
  • El Midaoui A., Imen Ghzaiel, Dominique Vervandier-Fasseur, Mohamed Ksila, Amira ZARROUK, Thomas Nury, Khallouki F., Aboubaker El hessni, Salama Ouazzani Ibrahimi, Norbert Latruffe, Réjean Couture, Omar, Kharoubi, Brahmi F., Sonia Hammami, Olfa Masmoudi-Kouki, Mohammed Hammami, Taoufik Ghrairi, Anne Vejux Lizard G. (2022). Saffron (crocus sativus L): a source of nutrients for the health and  or the treatment of neuropsychiatric and age-related diseases. Nutrients, accepté IF 5.
  • Essadek S, Bouchab H, El Kebbaj R, Gondcaille C, El Kamouni S, Savary S, Vamecq J, Essamadi A, Cherkaoui-Malki M, Nasser B, Andreoletti P. Effects of a Short-Term Lipopolysaccharides Challenge on Mouse Brain and Liver Peroxisomal Antioxidant and β-oxidative Functions: Protective Action of Argan Oil. Pharmaceuticals (Basel). 2022 Apr 12;15(4):465. doi: 10.3390/ph15040465. PMID: 35455460.
  • Ghzaiel I, Zarrouk A, Essadek S, Martine L, Hammouda S, Yammine A, Ksila M, Nury T, Meddeb W, Tahri Joutey M, Mihoubi W, Caccia C, Leoni V, Samadi M, Acar N, Andreoletti P, Hammami S, Ghrairi T, Vejux A, Hammami M, Lizard G - Protective effects of milk thistle (Sylibum marianum) seed oil and ?-tocopherol against 7?-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: Nutritional insights associated with the concept of pexotherapy. Steroids (2022), doi: 10.1016/j.steroids.2022.109032
  • Kelani H, Nuovo G, Bratasz A, Rajan J, Efanov AA, Michaille J-J, Awad H, Tili E. Microrna mir-155 activity in mouse ChAT+ neurons is critical for the rates of early and late paraplegia after transient aortic cross-clamping. Front. Mol. Neurosci. 2022 (accepted January 10, 2022) xx :xx, doi: 10.3389/fnmol.2022.788301
  • Nuovo GJ, Suster D, Awad H, Michaille JJ, Tili E. The histologic and molecular correlates of liver disease in fatal COVID-19 including with alcohol use disorder. Ann Diagn Pathol. 2022 Apr;57:151881. doi: 10.1016/j.anndiagpath.2021.151881. Epub 2021 Dec 23. PMID: 34968863 Free PMC article.
  • Silva P.  & N. Latruffe (2022) Benefits of the Mediterranean Diet-Wine Association: Role of Components. Molecules IF4,41
  • Thandapilly SJ , Louis XL, Kalt W, Raj Z ,LeMaistre JL,  Aloud BM, Vinqvist M, Yu L, Kaminski J, Latruffe N, Anderson CM, Anderson HD, Netticadan T (2022) "Effects of blueberry polyphenolic extract on vascular remodeling in spontaneously hypertensive rats". J Food Biochem IF 2,72. (accepté)



Nuovo GJ, Magro C, Shaffer T, Awad H, Suster D, Mikhail S, He B, Michaille JJ, Liechty B, Tili E. Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein. Ann Diagn Pathol. 2021 Apr;51:151682. doi: 10.1016/j.anndiagpath.2020.151682. PMID: 33360731

Nuovo GJ, Suster D, Awad H, Michaille JJ, Tili E. The histologic and molecular correlates of liver disease in fatal COVID-19 including with alcohol use disorder. Ann Diagn Pathol. 2021 Dec 23;57:151881. doi: 10.1016/j.anndiagpath.2021.151881. PMID: 34968863

Awad H, Tili E, Nuovo G, Kelani H, Ramadan ME, Williams J, Binzel K, Rajan J, Mast D, Efanov AA, Rasul KB, Moore S, Basso M, Mikhail A, Eltobgy M, Malbrue RA, Bourekas E, Oglesbee M, Bergdall V, Knopp M, Michaille JJ, El-Sayed H. Endovascular repair and open repair surgery of thoraco-abdominal aortic aneurysms cause drastically different types of spinal cord injury. Sci Rep. 2021 Apr 9;11(1):7834. doi: 10.1038/s41598-021-87324-6. PMID: 33837260

Tahri-Joutey M, Andreoletti P, Surapureddi S, Nasser B, Cherkaoui-Malki M, Latruffe N. Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARα. Int J Mol Sci. 2021 Aug 20;22(16):8969. doi: 10.3390/ijms22168969. PMID: 34445672 Free PMC article. Review.

Sahakyan N, Andreoletti P, Cherkaoui-Malki M, Petrosyan M, Trchounian A. Artemisia dracunculus L. essential oil phytochemical components trigger the activity of cellular antioxidant enzymes. J Food Biochem. 2021 Apr;45(4):e13691. doi: 10.1111/jfbc.13691. Epub 2021 Mar 10. PMID: 33694172

Papegay B, Nuyens V, Albert A, Cherkaoui-Malki M, Andreoletti P, Leo O, Kruys V, Boogaerts JG, Vamecq J. Adenosine Diphosphate and the P2Y13 Receptor Are Involved in the Autophagic Protection of Ex Vivo Perfused Livers From Fasted Rats: Potential Benefit for Liver Graft Preservation. Liver Transpl. 2021 Jul;27(7):997-1006. doi: 10.1002/lt.25970. Epub 2021 Feb 17. PMID: 33306256

Tawbeh A, Gondcaille C, Trompier D, Savary S. Peroxisomal ABC Transporters: An Update . Int. J. Mol. Sci. 2021, 22, 6093. 

Ghzaiel I, Sassi K, Zarrouk A, Nury T, Ksila M, Leoni V, Bouhaouala-Zahar B, Hammami S, Hammami M, Mackrill JJ, Samadi M, Ghrairi T, Vejux A, Lizard G. 7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19 J Steroid Biochem Mol Biol. 2021 Sep; 212: 105939. Published online 2021 Jun 9. doi: 10.1016/j.jsbmb.2021.105939 - PMCID: PMC8188774



Lizard G, Latruffe N, Vervandier-Fasseur D Aza- and Azo-Stilbenes: Bio-Isosteric Analogs of Resveratrol Molecules. 2020 Feb; 25(3): 605. PMCID: PMC7037676

Masmoudi-Kouki O. , Namsi A. , Hamdi Y., Bahdoudi S., Ghouili I., Chuquet J., Leprince J., Lefranc B., Ghrairi T., Tonon M.-C., Lizard G., Vaudry D. Cytoprotective and Neurotrophic Effects of Octadecaneuropeptide (ODN) in in vitro and in vivo Models of Neurodegenerative Diseases. Front Endocrinol (Lausanne) 2020; 11: 566026. Published online 2020 Nov 4. doi: 10.3389/fendo.2020.566026 - PMCID: PMC7672186

Nury T, Doria M, Lizard G, Vejux A Docosahexaenoic Acid Attenuates Mitochondrial Alterations and Oxidative Stress Leading to Cell Death Induced by Very Long-Chain Fatty Acids in a Mouse Oligodendrocyte Model Int J Mol Sci. 2020 Jan; 21(2): 641. PMCID: PMC7014165

Nury T, Lizard G, Vejux A Lipids Nutrients in Parkinson and Alzheimer’s Diseases: Cell Death and Cytoprotection Int J Mol Sci. 2020 Apr; 21(7): 2501. PMCID: PMC7178281

Singh N, Millot N, Maurizi L, Lizard G, Kumar G Taurine-Conjugated Mussel-Inspired Iron Oxide Nanoparticles with an Elongated Shape for Effective Delivery of Doxorubicin into the Tumor Cells ACS Omega. 2020 Jul 7; 5(26): 16165–16175. PMCID: PMC7346241

Sruthi S, Nury T, Millot N, Lizard G. Evidence of a non-apoptotic mode of cell death in microglial BV-2 cells exposed to different concentrations of zinc oxide nanoparticles. Environ Sci Pollut Res Int. 2020 Oct 20. doi: 10.1007/s11356-020-11100-8. Epub ahead of print. PMID: 33083954.

Yammine A, Nury T, Vejux A, Latruffe N, Vervandier-Fasseur D, Samadi M, Greige-Gerges H, Auezova L, Lizard G. Prevention of 7-Ketocholesterol-Induced Overproduction of Reactive Oxygen Species, Mitochondrial Dysfunction and Cell Death with Major Nutrients (Polyphenols, ω3 and ω9 Unsaturated Fatty Acids) of the Mediterranean Diet on N2a Neuronal Cells. Molecules. 2020;25(10):E2296. doi:10.3390/molecules25102296

Yammine A, Zarrouk A, Nury T, Vejux A, Latruffe N, Vervandier-Fasseur D, Samadi M, Mackrill JJ, Greige-Gerges H, Auezova L, Lizard G. Prevention by Dietary Polyphenols (Resveratrol, Quercetin, Apigenin) Against 7-Ketocholesterol-Induced Oxiapoptophagy in Neuronal N2a Cells: Potential Interest for the Treatment of Neurodegenerative and Age-Related Diseases. Cells. 2020 Oct 23;9(11):2346. doi: 10.3390/cells9112346. PMID: 33114025; PMCID: PMC7690753.

 Zarrouk A, Hammouda S, Ghzaiel I, Hammami S, Khamlaoui W, Ahmed SH, Lizard G, Hammami M. Association Between Oxidative Stress and Altered Cholesterol Metabolism in Alzheimer's Disease Patients. Curr Alzheimer Res. 2020 Dec 3. doi: 10.2174/1567205017666201203123046. Epub ahead of print. PMID: 33272182.



Ciron J, Cobo-Calvo A, Audoin B, Bourre B, Brassat D, Cohen M, Collongues N, Deschamps R, Durand-Dubief F, Laplaud D, Maillart E, Papeix C, Zephir H, Bereau M, Brochet B, Carra-Dallière C, Derache N, Gagou-Scherer C, Henry C, Kerschen P, Mathey G, Maubeuge N, Maurousset A, Montcuquet A, Moreau T, Prat C, Taithe F, Thouvenot E, Tourbah A, Rollot F, Vukusic S, Marignier R. Frequency and characteristics of short versus longitudinally extensive myelitis in adults with MOG antibodies: A retrospective multicentric study. Mult Scler. 2019 May 31:Vol 26, Issue 8, 2020

Di Cara F, Andreoletti P, Trompier D, Vejux A, Bülow MH, Sellin J, Lizard G, Cherkaoui-Malki M, Savary S. Peroxisomes in Immune Response and Inflammation. Int J Mol Sci. 2019 Aug 8;20(16).

Doria M, Nury T, Delmas D, Moreau T, Lizard G, Vejux A. Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model. Free Radic Biol Med. 2019 Jun;137:46-58.

 Fouache A, Zabaiou N, De Joussineau C, Morel L, Silvente-Poirot S, Namsi A, Lizard G, Poirot M, Makishima M, Baron S, Lobaccaro JA, Trousson A. Flavonoids differentially modulate liver X receptors activity-Structure-function relationship analysis. J Steroid Biochem Mol Biol. 2019 Jun;190:173-182.

Koss-Mikołajczyk I, Baranowska M, Todorovic V, Albini A, Sansone C, Andreoletti P, Cherkaoui-Malki M, Lizard G, Noonan D, Sobajic S, Bartoszek A. Prophylaxis of non-communicable diseases: Why fruits and vegetables may be better chemopreventive agents than dietary supplements based on isolated phytochemicals? Curr Pharm Des. 2019 Jul 1. [Epub ahead of print]

Lavie C, Rollot F, Durand-Dubief F, Marignier R, Ionescu I, Casey R, Moreau T, Tourniaire P, Hutchinson M, D'Hooghe MB, Laplaud DA, Clavelou P, De Sèze J, Debouverie M, Brassat D, Pelletier J, Lebrun-Frenay C, Le Page E, Castelnovo G, Berger E, Hautecoeur P, Heinzlef O, Durelli L, Clerico M, Trojano M, Patti F, Vukusic S; PRIMS and POPARTMUS. Neuraxial analgesia is not associated with an increased risk of post-partum relapses in MS. investigators. Mult Scler. 2019 Apr;25(4):591-600.

Lebrun-Frenay C, Moulignier A, Pierrot-Deseilligny C, Benrabah R, Moreau T, Lubetzki C, Monchecourt F; Copaxone Observatory. Five-year outcome in the copaxone observatory: a nationwide cohort of patients with multiple sclerosis starting treatment with glatiramer acetate in France. J Neurol. 2019 Apr;266(4):888-901.

A. Namsi, T. Nury, A.S. Khan, J. Leprince, D. Vaudry, C. Caccia, V. Leoni, A.G. Atanasov, M.-C. Tonon, O. Masmoudi-Kouki, G. Lizard. Octadecaneuropeptide (ODN) Induces N2a Cells Differentiation through a PKA/PLC/PKC/MEK/ERK-Dependent Pathway: Incidence on Peroxisome, Mitochondria, and Lipid Profiles.Molecules. 2019 Sep; 24(18): 3310. Published online 2019 Sep 11. doi: 10.3390/molecules24183310 - PMCID: PMC6767053

 Singh N, Sallem F, Mirjolet C, Nury T, Sahoo SK, Millot N, Kumar R. Polydopamine Modified Superparamagnetic Iron Oxide Nanoparticles as Multifunctional Nanocarrier for Targeted Prostate Cancer Treatment. Nanomaterials (Basel). 2019 Jan 22;9(2).

Raas Q, Saih FE, Gondcaille C, Trompier D, Hamon Y, Leoni V, Caccia C, Nasser B, Jadot M, Ménétrier F, Lizard G, Cherkaoui-Malki M, Andreoletti P, Savary S. A microglial cell model for acyl-CoA oxidase 1 deficiency Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Apr;1864(4):567-576.

Raas Q, Gondcaille C, Hamon Y, Leoni V, Caccia C, Menetrier F, Lizard G, Trompier D, Savary S. CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: novel microglial models for X-linked Adrenoleukodystrophy - Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):704-714

Sallem F, Haji R, Vervandier-Fasseur D, Nury T, Maurizi L, Boudon J, Lizard G, Millot N. Elaboration of Trans-Resveratrol Derivative-Loaded Superparamagnetic Iron Oxide Nanoparticles for Glioma Treatment. Nanomaterials (Basel). 2019 Feb 18;9(2).

Sassi K, Nury T, Zarrouk A, Sghaier R, Khalafi-Nezhad A, Vejux A, Samadi M, Aissa-Fennira FB, Lizard G. Induction of a non-apoptotic mode of cell death associated with autophagic characteristics with steroidal maleic anhydrides and 7β-hydroxycholesterol on glioma cells. J Steroid Biochem Mol Biol. 2019 Jul;191:105371. Epub 2019 Apr 26.

Sghaier R, Zarrouk A, Nury T, Badreddine I, O'Brien N, Mackrill JJ, Vejux A, Samadi M, Nasser B, Caccia C, Leoni V, Moreau T, Cherkaoui-Malki M, Salhedine Masmoudi A, Lizard G. Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes. Free Radic Res. 2019 May;53(5):535-561.

Silva P, Sureda A, Tur JA, Andreoletti P, Cherkaoui-Malki M, Latruffe N. How efficient is resveratrol as an antioxidant of the Mediterranean Diet, towards alterations during the aging process? Free Radic Res. 2019 May 1:1-311.

Tur JA, Jacob C, Chaimbault P, Tadayyon M, Richling E, Hermans N, Nunes Dos Santos C, Diederich M, Giblin L, Elhabiri M, Gaucher C, Andreoletti P, Fernandes A, Davies M, Bartoszek A, Cherkaoui-Malki M. Personalized nutrition in ageing society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112). Free Radic Res. 2019 Feb 22:1-8.



Bezine M, Namsi A, Sghaier R, Ben Khalifa R, Hamdouni H, Brahmi F, Badreddine I, Mihoubi W, Nury T, Vejux A, Zarrouk A, de Sèze J, Moreau T, Nasser B, Lizard G. The effect of oxysterols on nerve impulses.Biochimie. 2018 Oct;153:46-51. doi: 10.1016/j.biochi.2018.04.013. Epub 2018 Apr 21. Review - PMID: 29684511

Bezine M, Maatoug S, Ben Khalifa R, Debbabi M, Zarrouk A, Wang Y, Griffiths WJ, Nury T, Samadi M, Vejux A, de Sèze J, Moreau T, Kharrat R, El Ayeb M, Lizard G. Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0).Biochimie. 2018 Oct;153:56-69. doi: 10.1016/j.biochi.2018.02.008. Epub 2018 Feb 17 - PMID: 29462682

Brahmi F, Vejux A, Sghaier R, Zarrouk A, Nury T, Meddeb W, Rezig L, Namsi A, Sassi K, Yammine A, Badreddine I, Vervandier-Fasseur D, Madani K, Boulekbache-Makhlouf L, Nasser B, Lizard G. Prevention of 7-ketocholesterol-induced side effects by natural compounds.Crit Rev Food Sci Nutr. 2018 Oct 16:1-20. doi: 10.1080/10408398.2018.1491828. [Epub ahead of print] - PMID: 29993272

Brahmi F, Nury T, Debbabi M, Hadj-Ahmed S, Zarrouk A, Prost M, Madani K, Boulekbache-Makhlouf L, Lizard G. Evaluation of Antioxidant, Anti-Inflammatory and Cytoprotective Properties of Ethanolic Mint Extracts from Algeria on 7-Ketocholesterol-Treated Murine RAW 264.7 Macrophages. Antioxidants (Basel). 2018 Dec 6;7(12). pii: E184. doi: 10.3390/antiox7120184 - PMID: 30563252

Denimal D, Nguyen A, Fromont A, Moreau T, Vergès B, Duvillard L. Interferences of biotin therapy on immunoassays: It is time for a long-term solution! Presse Med. 2018 Jan;47(1):95-97Denimal D, Nguyen A, Fromont A, Moreau T, Vergès B, Duvillard L. Interferences of biotin therapy on immunoassays: It is time for a long-term solution! Presse Med. 2018 Jan;47(1):95-97

Hadj Ahmed S, Kharroubi W, Kaoubaa N, Zarrouk A, Batbout F, Gamra H, Najjar MF, Lizard G, Hininger-Favier I, Hammami M. Correlation of trans fatty acids with the severity of coronary artery disease lesions.Lipids Health Dis. 2018 Mar 15;17(1):52. doi: 10.1186/s12944-018-0699-3 - PMID: 29544473

Latruffe N, Vervandier-Fasseur D. Strategic Syntheses of Vine and Wine Resveratrol Derivatives to Explore their Effects on Cell Functions and Dysfunctions. Diseases. 2018 Dec 11;6(4). pii: E110. doi: 10.3390/diseases6040110. Review - PMID: 30545015

Meddeb W, Rezig L, Zarrouk A, Nury T, Vejux A, Prost M, Bretillon L, Mejri M, Lizard G. Cytoprotective Activities of Milk Thistle Seed Oil Used in Traditional Tunisian Medicine on 7-Ketocholesterol and 24S-Hydroxycholesterol-Induced Toxicity on 158N Murine Oligodendrocytes.Antioxidants (Basel). 2018 Jul 19;7(7). pii: E95. doi: 10.3390/antiox7070095 - PMID: 30029553 

Namsi A, Nury T, Hamdouni H, Yammine A, Vejux A, Vervandier-Fasseur D, Latruffe N, Masmoudi-Kouki O, Lizard G. Induction of Neuronal Differentiation of Murine N2a Cells by Two Polyphenols Present in the Mediterranean Diet Mimicking Neurotrophins Activities: Resveratrol and Apigenin.Diseases. 2018 Jul 22;6(3). pii: E67. doi: 10.3390/diseases6030067 - PMID: 30037152 

Nury T, Sghaier R, Zarrouk A, Ménétrier F, Uzun T, Leoni V, Caccia C, Meddeb W, Namsi A, Sassi K, Mihoubi W, Riedinger JM, Cherkaoui-Malki M, Moreau T, Vejux A, Lizard G. Induction of peroxisomal changes in oligodendrocytes treated with 7-ketocholesterol: Attenuation by α-tocopherol. Biochimie. 2018 Oct;153:181-202. doi: 10.1016/j.biochi.2018.07.009. Epub 2018 Jul 19 - PMID: 30031877

Shaaban S, Vervandier-Fasseur D, Andreoletti P, Zarrouk A, Richard P, Negm A, Manolikakes G, Jacob C, Cherkaoui-Malki M. Cytoprotective and antioxidant properties of organic selenides for the myelin-forming cells, oligodendrocytes.Bioorg Chem. 2018 Oct;80:43-56. doi: 10.1016/j.bioorg.2018.05.019. Epub 2018 May 21 - PMID: 29864687

Sruthi S, Maurizi L, Nury T, Sallem F, Boudon J, Riedinger JM, Millot N, Bouyer F, Lizard G. Cellular interactions of functionalized superparamagnetic iron oxide nanoparticles on oligodendrocytes without detrimental side effects: Cell death induction, oxidative stress and inflammation. Colloids Surf B Biointerfaces. 2018 Oct 1;170:454-462. doi: 10.1016/j.colsurfb.2018.06.041. Epub 2018 Jun 19. - PMID: 29958160

Sruthi S, Loiseau A, Boudon J, Sallem F, Maurizi L, Mohanan PV, Lizard G, Millot N. In vitro interaction and biocompatibility of titanate nanotubes with microglial cells. Toxicol Appl Pharmacol. 2018 Jun 13;353:74-86. doi: 10.1016/j.taap.2018.06.013. [Epub ahead of print] - PMID: 29908245

Tourbah A, Gout O, Vighetto A, Deburghgraeve V, Pelletier J, Papeix C, Lebrun-Frenay C, Labauge P, Brassat D, Toosy A, Laplaud DA, Outteryck O, Moreau T, Debouverie M, Clavelou P, Heinzlef O, De Sèze J, Defer G, Sedel F, Arndt C. MD1003 (High-Dose Pharmaceutical-Grade Biotin) for the Treatment of Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Study. CNS Drugs. 2018 Jul;32(7):661-672.

Vamecq J, Andreoletti P, El Kebbaj R, Saih FE, Latruffe N, El Kebbaj MHS, Lizard G, Nasser B, Cherkaoui-Malki M. Peroxisomal Acyl-CoA Oxidase Type 1: Anti-Inflammatory and Anti-Aging Properties with a Special Emphasis on Studies with LPS and Argan Oil as a Model Transposable to Aging. Oxid Med Cell Longev. 2018 Mar 25;2018:6986984. doi: 10.1155/2018/6986984. eCollection 2018. Review - PMID: 29765501 Free PMC Article

Vejux A, Namsi A, Nury T, Moreau T, Lizard G. Biomarkers of Amyotrophic Lateral Sclerosis: Current Status and Interest of Oxysterols and Phytosterols. Front Mol Neurosci. 2018 Jan 31;11:12. doi: 10.3389/fnmol.2018.00012. eCollection 2018. Review. - PMID: 29445325 

Vukusic S, Casey R, Rollot F, Brochet B, Pelletier J, Laplaud DA, De Sèze J, Cotton F, Moreau T, Stankoff B, Fontaine B, Guillemin F, Debouverie M, Clanet M; the OFSEP Investigators. Observatoire Français de la Sclérose en Plaques (OFSEP): A unique multimodal nationwide MS registry in France. Mult Scler. 2018 Dec 13:1352458518815602. doi: 10.1177/1352458518815602. [Epub ahead of print]

Zarrouk A, Debbabi M, Bezine M, Karym EM, Badreddine A, Rouaud O, Moreau T, Cherkaoui-Malki M, El Ayeb M, Nasser B, Hammami M, Lizard G. Lipid Biomarkers in Alzheimer's Disease.
Curr Alzheimer Res. 2018 Feb 22;15(4):303-312. doi: 10.2174/1567205014666170505101426.- PMID: 28474568


Andreoletti P, Raas Q, Gondcaille C, Cherkaoui-Malki M, Trompier D, Savary S. Predictive Structure and Topology of Peroxisomal ATP-Binding Cassette (ABC) Transporters. Int J Mol Sci. 2017 Jul 22; 18 (7) : 1593-1607.

Badreddine A, Zarrouk A, Karym E-M, Debbabi M, Nury T, Meddeb W, Sghaier R, Bezine M, Vejux A, Martine L, Grégoire S, Bretillon L, Prost-Camus E, Durand P, Prost M, Moreau M, Cherkaoui-Malki M, Nasser B, Lizard G. Benefits of argan oil on organel dysfunction, oxidative stress and cell death in 7-ketocholesterol-treated 158N murine oligodendrocytes: potential interest of argan oil for the prevention of neurodegenerative diseases. Int J Mol Sci. 2017 Oct 23; 18(10).

Bezine M, Debbabi M, Nury T, Ben-Khalifa R, Samadi M, Cherkaoui-Malki M, Vejux A, de Sèze J, Moreau T, El-Ayeb M, Lizard G. Evidence of K+ homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes. Chem. Phys. Lipids. 2017; 207:135-150.

Brahmi F, Hadj-Ahmed S, Zarrouk A, Bezine M, Nury T, Madani K, Chibane M, Vejux A, Andreoletti P, Boulekbache-Makhlouf L, Lizard G. Evidence of biological activity of Mentha species extracts on apoptotic and autophagic targets on murine RAW264.7 and human U937 monocytic cells. Pharm Biol. 2017 Dec; 55(1):286-293.

Cohen M, Brochet B, Clavelou P, Le Page E, Vermersch P, Tourbah A, Moreau T, Joly H, Sakarovitch C, Lebrun C; Qualicis Study Group. Cognition and quality of life in clinically isolated syndrome patients starting a disease modifying therapy in the QUALICIS study may not predict treatment response at one year. J Neurol Sci. 2017 (Nov 15) 382:73-78.

Debbabi M, Nury T, Helali I, Karym EM, Geillon F, Gondcaille C, Trompier D, Najid A, Terreau S, Bezine M, Zarrouk A, Vejux A, Andreoletti P, Cherkaoui-Malki M, Savary S, Lizard G. Flow Cytometric Analysis of the Expression Pattern of Peroxisomal Proteins, Abcd1, Abcd2, and Abcd3 in BV-2 Murine Microglial Cells. Methods Mol Biol 2017; 1595:257-265.

Debbabi M, Zarrouk A, Bezine M, Meddeb W, Nury T, Badreddine A, Karym EM, Sghaier R, Bretillon L, Guyot S, Samadi M, Cherkaoui-Malki M, Nasser B, Mejri M, Ben-Hammou S, Hammami M, Lizard G. Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells. Chem Phys Lipids. 2017; 207:151-170.

El Kamouni S, El Kebbaj R, Andreoletti P, El Ktaibi A, Rharrassi I, Essamadi A, El Kebbaj MS, Mandard S, Latruffe N, Vamecq J, Nasser B, Cherkaoui-Malki M. Protective Effect of Argan and Olive Oils against LPS-Induced Oxidative Stress and Inflammation in Mice Livers. Int J Mol Sci. 2017; 18 (10): 2981-2996.

Fissolo N, Pignolet B, Matute-Blanch C, Triviño JC, Miró B, Mota M, et al. Matrix metalloproteinase 9 is decreased in natalizumab-treated multiple sclerosis patients at risk for progressive multifocal leukoencephalopathy. Ann Neurol. 2017 Aug;82(2):186-195.

Foulon S, Maura G, Dalichampt M, Alla F, Debouverie M, Moreau T, Weill A. Prevalence and mortality of patients with multiple sclerosis in France in 2012: a study based on French health insurance data. J Neurol. 2017 Jun; 264(6):1185-1192.

Geillon F, Gondcaille C, Raas Q, Dias AMM, Pecqueur D, Truntzer C, Lucchi G, Ducoroy P, Falson P, Savary S, Trompier D. Peroxisomal ATP-binding cassette transporters form mainly tetramers. J Biol Chem. 2017; 292(17):6965-6977.

Hadj Ahmed S, Kaoubaa N, Kharroubi W, Zarrouk A, Najjar MF, Batbout F, Gamra H, Lizard G, Hammami M. Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients. Lipids Health Dis. 2017 Aug 14;16(1):154. PMID: 28806974Hadj Ahmed S, Kaoubaa N, Kharroubi W, Zarrouk A, Najjar MF, Batbout F, Gamra H, Lizard G, Hammami M. Lipids Health Dis. 2017 14;16(1):154.

Hadj Ahmed S, Koubaa N, Kharroubi W, Zarrouk A, Mnari A, Batbout F, Gamra H, Hammami S, Lizard G, Hammami M. Identification of long and very long chain fatty acids, plasmalogen-C16:0 and phytanic acid as new lipid biomarkers in Tunisian coronary artery disease patients. Prostaglandins Other Lipid Mediat. 2017; 131:49-58.

Haj Ahmed S, Kharroubi W, Zarrouk A, Brahmi F, Nury T, Lizard G, Hammami M. Protective effects of bezafibrate against elaidic acid-induced accumulation of lipid droplets in monocytic cells. Curr Res Transl Med. 2017;65(1):20-30.

Kharroubi W, Haj Ahmed S, Nury T, Andreoletti P, Sakly R, Hammami M, Lizard G. Mitochondrial dysfunction, oxidative stress and apoptotic induction in microglial BV-2 cells treated with sodium arsenate. J Environ Sci (China). 2017; 51:44-51.

Kharroubi W, Nury T, Ahmed SH, Andreoletti P, Sakly R, Hammami M, Lizard G. Induction by arsenate of cell-type-specific cytotoxic effects in nerve and hepatoma cells. Hum Exp Toxicol. 2017; 36(12):1256-1269.

Latruffe N. Natural Products and Inflammation. Molecules. 2017 Jan 12; 22(1). PMID: 28085099

Leoni V, Nury T, Vejux A, Zarrouk A, Caccia C, Debbabi M, Fromont A, Sghaier R, Moreau T, Lizard G. Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, cholesterol and cholesterol precursors. J Steroid Biochem Mol Biol. 2017;169:96-110.

Lizard G, Filali-Zegzouti Y, Midaoui AE. Benefits of Argan Oil on Human Health-May 4-6 2017, Errachidia, Morocco. Int J Mol Sci. 2017 Jun 28;18(7).

Meddeb W, Rezig L, Abderrabba M, Lizard G, Mejri M. Tunisian Milk Thistle: An Investigation of the Chemical Composition and the Characterization of Its Cold-Pressed Seed Oils. Int J Mol Sci. 2017 Dec 2;18(12). PMID: 29207484

Monnier A, Prigent-Tessier A, Quirie A, Bertrand N, Savary S, Gondcaille C, Garnier P, Demougeot C, Marie C. Brain-derived neurotrophic factor of the cerebral microvasculature: a forgotten and nitric oxide-dependent contributor of brain-derived neurotrophic factor in the brain. Acta Physiol 2017; 219 (4):790-802.

Montcuquet A, Collongues N, Papeix C, Zephir H, Audoin B, Laplaud D, Bourre B, Brochet B, Camdessanche JP, Labauge P, Moreau T, Brassat D, Stankoff B, de Seze J, Vukusic S, Marignier R; NOMADMUS study group and the Observatoire Français de la Sclérose en Plaques (OFSEP). Effectiveness of mycophenolate mofetil as first-line therapy in AQP4-IgG, MOG-IgG, and seronegative neuromyelitis optica spectrum disorders. Mult Scler. 2017 Sep; 23(10):1377-1384.

Moreau T, Bungener C, Heinzlef O, Suchet L, Borgel F, Bourdeix I, Meite M, Rerat K, Chouette I; GRACE Study Group. Anxiety and Coping Strategy Changes in Multiple Sclerosis Patients Initiating Fingolimod: The GRACE Prospective Study. Eur Neurol. 2017; 77(1-2):47-55.

Nury T, Zarrouk A, Ragot K, Debbabi M, Riedinger J M, Vejux A, Aubourg P, Lizard G. 7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD. The Journal of steroid biochemistry and molecular biology. 2017 May; 169:123-136.

Rouzaud C, Hautecoeur P, Donze C, Heinzlef O, Dinh A, et al. Treating asymptomatic bacteriuria before immunosuppressive therapy during multiple sclerosis: Should we do it? Mult Scler Relat Disord. 2017 Nov; 18:161-163.

Saih FE, Andreoletti P, Mandard S, Latruffe N, El Kebbaj MS, Lizard G, Nasser B, Cherkaoui-Malki M. Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides. Molecules. 2017 Jan 7; 22(1): 102-104.

Samadi M, Nury T, Khalafi-Nezhad A, Lizard G. Protecting group-free radical decarboxylation of bile acids: Synthesis of novel steroidal substituted maleic anhydrides and maleimides and evaluation of their cytotoxicity on C6 rat glioma cells. Steroids. 2017 Sep; 125:124-130.

Zarrouk A, Debbabi M, Bezine M, Karym EM, Badreddine A, Rouaud O, Moreau T, Cherkaoui-Malki M, El Ayeb M, Nasser B, Hammami M, Lizard G. Lipid Biomarkers in Alzheimer's Disease. Curr Alzheimer Res. 2017 ; doi: 10.2174/1567205014666170505101426. [Epub ahead of print] PMID: 28474568.

Zarrouk A, Nury T, Karym EM, Vejux A, Sghaier R, Gondcaille C, Andreoletti P, Trompier D, Savary S, Cherkaoui-Malki M, Debbabi M, Fromont A, Riedinger JM, Moreau T, Lizard G. Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes. J Steroid Biochem Mol Biol. 2017 May; 169:29-38.Zarrouk A, Nury T, Karym EM, Vejux A, Sghaier R, Gondcaille C, Andreoletti P, Trompier D, Savary S, Cherkaoui-Malki M, Debbabi M, Fromont A, Riedinger JM, Moreau T, Lizard G. Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes. J Steroid Biochem Mol Biol. 2017 May; 169:29-38.


Bessam FZ, Mehdadi Z, Lizard G, Djellouli R. Study of the antioxidant activity of the extracts of the achenes of Sylibum marianum L. Jour. Biochem. Intern. 3(2): 63-72, 2016 ISSN: 2454-4760

Debbabi M, Nury T, Zarrouk A, Mekahli N, Bezine M, Sghaier R, Grégoire S, Martine L, Durand P, Camus E, Vejux A, Jabrane A, Bretillon L, Prost M, Moreau T, Ammou SB, Hammami M, Lizard G. Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells. Int J Mol Sci. 2016 Nov 25;17(12). pii: E1973. PMID: 27897980

Doria M, Maugest L, Moreau T, Lizard G, Vejux A. Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson's disease. Free Radic Biol Med. 2016 Nov 9;101:393-400. doi: 10.1016/j.freeradbiomed.2016.10.008. [Epub ahead of print] Review. PMID: 27836779

Kharroubi, W.; Ahmed, S. H.; Nury, T.; Andreoletti, P.; Haouas, Z.; Zarrouk, A.; Sakly, R.; Hammami, M.; Lizard, G. Evidence of hormesis on human neuronal SK-N-BE cells treated with sodium arsenate: impact at the mitochondrial level. Environ Sci Pollut Res Int; 2016.

Klionsky, D. J.; Abdelmohsen, K.; …; Lizard, G.;et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222; 2016.

Lançon A, Frazzi R, Latruffe N. Anti-Oxidant, Anti-Inflammatory and Anti-Angiogenic Properties of Resveratrol in Ocular Diseases. Molecules. 2016 Mar 2;21(3).

Leoni, V.; Nury, T.; Vejux, A.; Zarrouk, A.; Caccia, C.; Debbabi, M.; Fromont, A.; Sghaier, R.; Moreau, T.; Lizard, G. Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with alpha-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, cholesterol and cholesterol precursors. The Journal of steroid biochemistry and molecular biology; 2016.

Limagne E, Lançon A, Delmas D, Cherkaoui-Malki M, Latruffe N. Resveratrol Interferes with IL1-β-Induced Pro-Inflammatory Paracrine Interaction between Primary Chondrocytes and Macrophages. Nutrients. 2016 May 11;8(5).

Monnier A., A. Prigent-Tessier, A. Quirie, N. Bertrand, S. Savary, C. Gondcaille, P. Garnier, C.Demougeot, C. Marie. Brain-derived neurotrophic factor of the cerebral microvasculature: a forgotten and nitric oxide-dependent contributor of brain-derived neurotrophic factor in the brain Acta Physiol (2016).Brain-derived neurotrophic factor of the cerebral microvasculature: a forgotten and nitric oxide-dependent contributor of brain-derived neurotrophic factor in the brain Acta Physiol (2016).

Nury, T.; Zarrouk, A.; Ragot, K.; Debbabi, M.; Riedinger, J. M.; Vejux, A.; Aubourg, P.; Lizard, G. 7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD. The Journal of steroid biochemistry and molecular biology; 2016.

Rihane, N.; Nury, T.; M'Rad, I.; El Mir, L.; Sakly, M.; Amara, S.; Lizard, G. Microglial cells (BV-2) internalize titanium dioxide (TiO) nanoparticles: toxicity and cellular responses. Environ Sci Pollut Res Int; 2016.

Saih FE, Andreoletti P, Mandard S, Latruffe N, El Kebbaj MS, Lizard G, Nasser B, Cherkaoui-Malki M. Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides. Molecules. 2017 Jan 7;22(1).

Tili E, Michaille JJ. Promiscuous Effects of Some Phenolic Natural Products on Inflammation at Least in Part Arise from Their Ability to Modulate the Expression of Global Regulators, Namely microRNAs. Molecules. 2016 Sep 21;21(9). pii: E1263. Review. PMID: 27657035

Vervandier-Fasseur D, Adrian M, Latruffe N (2016). Les hydroxystilbènes à propriétés anti-oxydantes et antitumorales : relation structure-activité. Regards sur la Biochimie, octobre 2016, pp 8-10

Zarrouk, A.; Nury, T.; Karym, E. M.; Vejux, A.; Sghaier, R.; Gondcaille, C.; Andreoletti, P.; Trompier, D.; Savary, S.; Cherkaoui-Malki, M.; Debbabi, M.; Fromont, A.; Riedinger, J. M.; Moreau, T.; Lizard, G. Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes. The Journal of steroid biochemistry and molecular biology; 2016.


Zarrouk, A., Nury, T., Dauphin, A. , Frère, P., Riedinger, J.M., Bachelet, C.M., Frouin, F., Moreau, T., Hammami, M., Kahn, E., Lizard, G. Impact of C24:0 on actin-microtubule interaction in human neuronal SK-N-BE cells: evaluation by FRET confocal spectral imaging microscopy after dual staining with rhodamine-phalloidin and tubulin tracker green. Func Neurol (2015, sous presse)

Nury, T., Zarrouk, A., Mackrill, J.J., Samadi, M., Durand, P., Riedinger, J.M., Doria, M., Vejux, A., Limagne, E., Delmas, D., Prost, M., Moreau, T., Hammami, M., Delage-Mourroux, R., O'Brien, N.M., Lizard, G. Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). Steroids. Feb 12. doi: 10.1016/j.steroids.2015.02.003 (2015).

Badreddine, A., El Mostafa, K., Zarrouk, A., Nury, T., El Kharrassi, Y., Nasser, B., Malki, M.C., Lizard, G., and Samadi, M. An expeditious synthesis of spinasterol and schottenol, two phytosterols present in argan oil and in cactus pear seed oil, and evaluation of their biological activities on cells of the central nervous system. Steroids 2015 Jan 13. doi: 10.1016/j.steroids.2015.01.005 (2015).

Zarrouk, A., Hammami, M., Moreau, T., and Lizard, G. Accumulation of 24S-hydroxycholesterol in neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0): Argument in favor of 24S-hydroxycholesterol as a potential biomarker of neurolipotoxicity. Rev Neurol (Paris) 171(2):125-129 (2015).

Zarrouk, A., Nury, T., Riedinger, J.M., Rouaud, O., Hammami, M., and Lizard, G. Dual Effect of Docosahexaenoic Acid (Attenuation or Amplification) on C22:0-, C24:0-, and C26:0-Induced Mitochondrial Dysfunctions and Oxidative Stress on Human Neuronal SK-N-BE Cells. J Nutr Health Aging 19(2): 198-205, (2015).

Zarrouk, A., Nury, T., Samadi, M., O'Callaghan, Y., Hammami, M., O'Brien, N.M., Lizard, G., and Mackrill, J.J. Effects of cholesterol oxides on cell death induction and calcium increase in human neuronal cells (SK-N-BE) and evaluation of the protective effects of docosahexaenoic acid (DHA; C22:6 n-3). Steroids: in press, Feb 2. doi: 10.1016 / j.steroids.2015.01.018 (2015).

Zarrouk, A., Riedinger, J.M., Ahmed, S.H., Hammami, S., Chaabane, W., Debbabi, M., Ben Ammou, S., Rouaud, O., Frih, M., Lizard, G., and Hammami, M.. Fatty Acid Profiles in Demented Patients: Identification of Hexacosanoic Acid (C26:0) as a Blood Lipid Biomarker of Dementia. J Alzheimers Dis 44(4):1349-59, (2015).


Aires V, Delmas D, Le Bachelier C, Latruffe N, Schlemmer D, Benoist JF, Djouadi Fand Bastin J. Stilbenes and resveratrol metabolites improve mitochondrial fatty acid oxidation defects in human fibroblasts.Orphanet Journal of Rare Diseases - MS : 1832484481121907 - IF 4,32

Cherkaoui-Malki M. A tribute to Christian de Duve (1917-2013). Biochimie. 2014 Mar;98:1-3 doi: 10.1016/j.biochi.2013.12.014. Epub 2013 Dec 31. IF 3.14

El Kharrassi Y, Samadi M, Lopez T, Nury T, El Kebbaj R, Andreoletti P, El Hajj HI, Vamecq J, Moustaid K, Latruffe N, El Kebbaj MS, Masson D, Lizard G, Nasser B, Cherkaoui-Malki M. Biological activities of Schottenol and Spinasterol, two natural phytosterols present in argan oil and in cactus pear seed oil, on murine miroglial BV2 cells.Biochem Biophys Res Commun. 2014;446:798-804.

El-Mostafa K, Kharrassi YE, Badreddine A, Andreoletti P, Vamecq J, Kebbaj MS, Latruffe N, Lizard G, Nasser B, Cherkaoui-Malki M. Nopal Cactus (Opuntia ficus-indica) as a Source of Bioactive Compounds for Nutrition, Health and Disease. Molecules 2014 19(9):14879-14901.

Geillon, F., Gondcaille, C., Charbonnier, S., Van Roermund, C.W., Lopez, T.E., Dias, A.M.M., Pais de Barros, J-P., Arnould, C., Wanders, R.J., Trompier, D. & Savary. S. Structure-Function Analysis of Peroxisomal ABC Transporters using Chimeric Dimers. J Biol Chem (2014), 289, 24511-20

Gondcaille C, Genin EC, Lopez TE, Dias AM, Geillon F, Andreoletti P, Cherkaoui-Malki M, Nury T, Lizard G, Weinhofer I, Berger J, Kase ET, Trompier D, Savary S. LXR antagonists induce ABCD2 expression Biochim Biophys Acta. 1841(2):259-266 (2014). IF 3.8

Khelifi M, Zarrouk A, Nury T, Hamed H, Saguem S, Salah RB, Riedinger JM, Lizard G. Cytokine and eicosanoid profiles of phosphate mine workers. J Toxicol Sci. 2014;39:465-74.

Limagne E, Cottet V, Cotte A, Rollot F, Hamza S, Hillon P, Latruffe N, Delmas D. Potential Role Of Oxidative Dna Damage In The Impact Of Pnpla3 Variant (Rs 738409 C<G) In Hcc Risk, Hepatology, 2014 Sep;60(3):1110-1. If 12 IF 12

Mazue F, Delmas D, Murillo G, Saleiro D, Limagne E, Latruffe N. Protective Effects Of Red Wine Extract In Colon Carcinogenesis : A Potential Synergism Of Red Wine Polyphenols. Food Funct. 2014, 5:663-70. If Moy 2,5 IF 2.5

Nicolas-Frances N, Arnauld S, Kaminski J, Ver Loren Van Themaat E, Clemencet M-C, Chamouton J, Athias A, Gresti J, Degrace P, Latruffe N, Mandard S. Disturbances In Cholesterol, Bile Acid And Glucose Metabolism In Peroxisomal 3-Ketoacylcoa Thiolase B Deficient Mice Fed Diets Containing High Or Low Saturated Fat Contents Biochimie (2014 Mar;98:86-101. doi: 10.1016/j.biochi.2013.11.014. Epub 2013 Nov 26.). If 3.1 IF 3.1

Nury T, Zarrouk A, Vejux A, Doria M, Riedinger JM, Delage-Mourroux R, Lizard G. Induction of oxiapoptophagy, a mixed mode of cell death associated with oxidative stress, apoptosis and autophagy, on 7-ketocholesterol-treated 158N murine oligodendrocytes: Impairment by α-tocopherol. Biochem Biophys Res Commun. 2014, 446:714-9.

Rommelaere S, Millet V, Vu Manh TP, Gensollen T, Andreoletti P, Cherkaoui-Malki M, Bourges C, Escalière B, Du X, Xia Y, Imbert J, Beutler B, Kanai Y, Malissen B, Malissen M, Tailleux A, Staels B, Galland F, Naquet P. Sox17 regulates liver lipid metabolism and adaptation to fasting. PLoS One. 2014, 9:e104925.

Trompier D, Vejux A, Zarrouk A, Gondcaille C, Geillon F, Nury T, Savary S, Lizard G. Brain peroxisomes Biochimie. 98:102-10 (2014) (Review) IF 3.14

Trompier D, Gondcaille C, Lizard G, Savary S. Regulation of the adrenoleukodystrophy-related gene (ABCD2): Focus on oxysterols and LXR antagonists. Biochem Biophys Res Commun. 2014 Jan 27. pii: S0006-291X(14)00040-0. doi: 10.1016/j.bbrc.2014.01.025. IF 2.40

Vamecq J, Cherkaoui-Malki M, Andreoletti P, Latruffe N. The human peroxisome. in health and disease: The story of an oddity becoming a vital organelle Biochimie. 2014 Mar;98C:4-15. doi: 10.1016/j.biochi.2013.09.019. Epub 2013 Sep 26. Review. PubMed PMID: 24075875." IF 3.14


 Aires V, Limagne E, Cotte A, Latruffe N, Ghiringhelli F, Delmas D. Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergizes with chemotherapeutic drugs to induce cell death. Mol Nutr Food Res. 201357:1170-1181. IF 4.3

Boumhras M, Ouafik S, Nury T, Gresti J, Athias A, Ragot K, Nasser B, Cherkaoui-Malki M, Lizard G. Determination of heavy metal content and lipid profiles in mussel extracts from two sites on the moroccan atlantic coast and evaluation of their biological activities on MIN6 pancreatic cells. Environ Toxicol. 2013 Mar 1.  [Epub ahead of print] IF 2.7

Demarquoy J. Meat adulteration: the use of PCR. Meat Sci. 2013 Jun 94(2):164. 

Dupuy AM, Kuster N, Lizard G, Ragot K, Lehmann S, Gallix B, Cristol JP. Performance evaluation of human cytokines profiles obtained by various multiplexed-based technologies underlines a need for standardization. Clin Chem Lab Med. 2013 Jan 9:1-9. IF 2.7

Frazzi R, Valli R, Tamagnini I, Casali B, Latruffe N, Merli F.Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation. Int J Cancer. 2013 Mar 1;132(5):1013-21. IF 6.2

Gondcaille C, Genin EC, Lopez TE, Dias AM, Geillon F, Andreoletti P, Cherkaoui-Malki M, Nury T, Lizard G, Weinhofer I, Berger J, Kase ET, Trompier D, Savary S. LXR antagonists induce ABCD2 expression. Biochim Biophys Acta. 2013. 13: S1388-1981(13)00245-X.

Isambert N, Fumoleau P, Paul C, Ferrand C, Zanetta S, Bauer J, Ragot K, Lizard G, Jeannin JF, Bardou M. Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors. BMC Cancer. 2013;13:172. IF 3.3

Lançon A, Michaille JJ, Latruffe N. Effects of dietary phytophenols on the expression of microRNAs involved in mammalian cell homeostasis. J Sci Food Agric. 2013; 93:3155-64.

Latruffe N, Rifler J-P. Bioactive polyphenols from grape and wine. Curr Pharmaceut Design 19, 2013 19:6053-6063 IF 3.3

Latruffe N. Remembrance to Professor Serge Renaud, for the twentieth year celebration of his discovery of the « French paradox ». J Wine Resaerch 2013 (sous presse).

Limagne E, Cottet V, Cotte A, Rollot F, Hamza S, Hillon P, Delmas D, Latruffe N. Potential role of oxidative DNA damage in the impact of PNPLA3 variant (rs 738409 C<G) in HCC risk. 2013 Hepatology 2014 Sep;60(3):1110-1. doi: 10.1002/hep.27004. Epub 2014 Jul 28.

Nury T, Samadi M, Varin A, Lopez T, Zarrouk A, Boumhras M, Riedinger JM, Masson D, Vejux A, Lizard G. Biological activities of the LXRα and β agonist, 4β-hydroxycholesterol, and of its isomer, 4α-hydroxycholesterol, on oligodendrocytes: effects on cell growth and viability, oxidative and inflammatory status. Biochimie. 2013; 95:518-530. IF 3.1

Ragot K, Mackrill JJ, Zarrouk A, Nury T, Aires V, Jacquin A, Athias A, Pais de Barros JP, Véjux A, Riedinger JM, Delmas D, Lizard G. Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. Biochem Pharmacol. 2013;86:67-79. IF 4.6

Rigault C, Le Borgne F, Tazir B, Benani A, Demarquoy J. A high-fat diet increases l-carnitine synthesis through a differential maturation of the Bbox1 mRNAs. Biochim Biophys Acta. 2013 Feb;1831(2):370-7. IF 3.8

Tili E, Michaille JJ, Croce CM. MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer. Immunol Rev. 2013; 253:167-184. IF 12.1

Trompier D, Vejux A, Zarrouk A, Gondcaille C, Geillon F, Nury T, Savary S, Lizard G. Brain peroxisomes. Biochimie. 2013 [Epub ahead of print] IF 3.1

Vamecq J, Cherkaoui-Malki M, Andreoletti P, Latruffe N. The human peroxisome in health and disease: The story of an oddity becoming a vital organelle. Biochimie. 2013 Sep 26. [Epub ahead of print] IF 3.1


Baarine M, Andréoletti P, Athias A, Nury T, Zarrouk A, Ragot K, Vejux A, Riedinger JM, Kattan Z, Bessede G, Trompier D, Savary S, Cherkaoui-Malki M, Lizard G. Evidence of oxidative stress in very long chain fatty acid - Treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins. Neuroscience. 2012 Jun 28;213:1-18. doi: 10.1016 /j. neuroscience. 2012.03.058. Epub 2012 Apr 19. IF moy 3.21

Baarine M, Ragot K, Athias A, Nury T, Kattan Z, Genin EC, Andreoletti P, Ménétrier F, Riedinger JM, Bardou M, Lizard G. Incidence of Abcd1 level on the induction of cell death and organelle dysfunctions triggered by very long chain fatty acids and TNF-α on oligodendrocytes and astrocytes. Neurotoxicology. 2012;33:212-228. IF moy 2.92

Carrillo C, Hichami A, Andreoletti P, Cherkaoui-Malki M, Del Mar Cavia M, Abdoul-Azize S, Alonso-Torre SR, Khan NA. Diacylglycerol-containing oleic acid induces increases in [Ca(2+)](i) via TRPC3/6 channels in human T-cells. Biochim Biophys Acta. 2012;1821:618-626. IF moy 4.51

Chalal M, Vedamurthy B, Spatafora C, Latruffe N, Vervandier-Fasseur D, Tringali C . Resveratrol dehydrodimers : laccase-mediated biomimetic synthesis and antiproliférative activities. Eur J Org Chem 27: 5217-5224. IF 3.2.

El Hajj HI, Vluggens A, Andreoletti P, Ragot K, Mandard S, Kersten S, Waterham HR, Lizard G, Wanders RJ, Reddy JK, Cherkaoui-Malki M. The Inflammatory Response in Acyl-CoA Oxidase 1 Deficiency (Pseudoneonatal Adrenoleukodystrophy). Endocrinology. 2012 Jun;153(6):2568-75. IF moy 4.99

Guerreiro R, Besson AA, Bellenger J, Ragot K, Lizard G, Faivre B, Sorci G. Correlational selection on pro- and anti-inflammatory effectors. Evolution. 2012 Nov;66(11):3615-23.

Kahn E, Tissot N, Frere P, Dauphin A, Boumhras M, Bachelet CM, Frouin F, Lizard G. Fluorescence excitation analysis by two-photon confocal laser scanning microscopy: a new method to identify fluorescent nanoparticles on histological tissue sections. Int J Nanomedicine. 2012;7:5545-54.

Kaminski J, Lançon A, Aires V, Limagne E, Tili E, Michaille JJ, Latruffe N. Resveratrol initiates differentiation of mouse skeletal muscle-derived C2C12 myoblasts. Biochem Pharmacol. 2012 Nov 15;84(10):1251-9, IF moy 4,7.

Kaminski J, Lançon, A, Tili E, Aires V, Demarquoy J, Lizard G, Michaille  J, Latruffe N. Dietary resveratrol modulates metabolic functions in skeletal muscle cells. J Food Drug Analysis, 2012, 20 suppl 1, 398-401. IF moy 0,8.

Lançon A, Kaminski J, Tili E, Michaille JJ, Latruffe N. Control of MicroRNA expression as a new way for resveratrol to deliver its beneficial effects. J Agric Food Chem. 2012 Sep 12;60(36):8783-9.

Le Borgne F, Guyot S, Logerot M, Beney L, Gervais P, Demarquoy J. Exploration of lipid metabolism in relation with plasma membrane properties of duchenne muscular dystrophy cells: influence of L-carnitine. PLoS One. 2012;7(11):e49346.

Nury T, Samadi M, Varin A, Lopez T, Zarrouk A, Boumhras M, Riedinger JM, Masson D, Vejux A, Lizard G. Biological activities of the LXRα and β agonist, 4β-hydroxycholesterol, and of its isomer, 4α-hydroxycholesterol, on oligodendrocytes: Effects on cell growth and viability, oxidative and inflammatory status. Biochimie. 2012 Dec 7. pii: S0300-9084(12)00472-5.

Pernodet N, Hermetet F, Adami P, Vejux A, Descotes F, Borg C, Adams M, Pallandre JR, Viennet G, Esnard F, Jouvenot M, Despouy G. High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients. Breast Cancer Res. 2012 Oct 25;14(5):R136. [Epub ahead of print]

Rifler JP, Lorcerie F, Durand P, Delmas D, Ragot K, Limagne E, Mazué F, Riedinger JM, d'Athis P, Hudelot B, Prost M, Lizard G, Latruffe N. A moderate red wine intake improves blood lipid parameters and erythrocytes membrane fluidity in post myocardial infarct patients. Mol Nutr Food Res. 2012;56:345-351. IF moy 4.71

Tili E, Michaille JJ, Luo Z, Volinia S, Rassenti LZ, Kipps TJ, Croce CM. The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state. Blood. 2012 Sep 27;120(13):2631-8.

Vejux A, Montange T, Martine L, Zarrouk A, Riedinger JM, Lizard G. Absence of Oxysterol-like Side Effects in Human Monocytic Cells Treated with Phytosterols and Oxyphytosterols. J Agric Food Chem. 2012;60:4060-4066.  IF moy 2.81

Zarrouk A, Vejux A, Nury T, El Hajj HI, Haddad M, Cherkaoui-Malki M, Riedinger JM, Hammami M, Lizard G. Induction of mitochondrial changes associated with oxidative stress on very long chain fatty acids (C22:0, C24:0, or C26:0)-treated human neuronal cells (SK-NB-E). Oxid Med Cell Longev. 2012;2012:623257.


 Baarine M, Thandapilly SJ, Louis XL, Mazué F, Yu L, Delmas D, Netticadan T, Lizard G, Latruffe N. Pro-apoptotic versus anti-apoptotic properties of dietary resveratrol on tumoral and normal cardiac cells. Genes Nutr. 2011;6:161-9. IF Moy 3.01

Coant N, Simon-Rudler M, Gustot T, Fasseu M, Gandoura S, Ragot K, Abdel-Razek W, Thabut D, Lettéron P, Ogier-Denis E, Ouziel R, Devière J, Lizard G, Tellier Z, Lebrec D, Moreau R. Glycogen synthase kinase 3 involvement in the excessive proinflammatory response to LPS in patients with decompensated cirrhosis. J Hepatol. 2011 Feb 17; IF Moy 7.81

Colin D, Limagne E, Jeanningros S, Jacquel A, Lizard G, Athias A, Gambert P, Hichami A, Latruffe N, Solary E, Delmas D. Endocytosis of resveratrol via lipi rafts and activation of downstream signaling pathways in cancer cells. Cancer Prev Res (Phila). 2011;4:1095-106.  IF moy. 6

Di Micco S, Mazué F, Daquino C, Spatafora C, Delmas D, Latruffe N, Tringali C, Riccio R, Bifulco G. Structural basis for the potential antitumour activity of DNA-interacting benzo[kl]xanthene lignans. Org Biomol Chem. 2011;9:701-10. IF moy 3.31

Fidaleo M, Arnauld S, Clémencet MC, Chevillard G, Royer MC, De Bruycker M, Wanders RJ, Athias A, Gresti J, Clouet P, Degrace P, Kersten S, Espeel M,Latruffe N, Nicolas-Francès V, Mandard S. A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver. Biochimie. 2011;93:876-91. IF 3.78

Genin EC, Geillon F, Gondcaille C, Athias A, Gambert P, Trompier D, Savary S. Substrate specificity overlap and interaction between adrenoleukodystrophy protein (ALDP/ABCD1) and adrenoleukodystrophy-related protein (ALDRP/ABCD2). J Biol Chem. 2011;286:8075-84. IF  moy 5.44

Huang J, Viswakarma N, Yu S, Jia Y, Bai L, Vluggens A, Cherkaoui-Malki M, Khan M, Singh I, Yang G, Rao MS, Borensztajn J, Reddy JK. Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice. Am J Pathol. 2011;179:703-13. IF moy. 6.03

Kahn E, Baarine M, Dauphin A, Ragot K, Tissot N, Seguin A, Ménétrier F, Kattan Z, Bachelet CM, Frouin F, Lizard G. Impact of 7-ketocholesterol and very long chain fatty acids on oligodendrocyte lipid membrane organization: evaluation via LAURDAN and FAMIS spectral image analysis. Cytometry A. 2011;79:293-305. 

Le Borgne F, Ben Mohamed A, Logerot M, Garnier E, Demarquoy J. Changes in carnitine octanoyltransferase activity induce alteration in fatty acid metabolism. Biochem Biophys Res Commun. 2011;409:699-704. 

Lizard G. Impact of phytosterols on mitochondrial functions. Br J Nutr. 2011;106:461-2. 

Ragot K, Delmas D, Athias A, Nury T, Baarine M, Lizard G. αlpha-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes. Chem Phys Lipids. 2011;164:469-78.

Rifler JP, Lorcerie F, Durand P, Delmas D, Ragot K, Limagne E, Mazué F, Riedinger JM, d'Athis P, Hudelot B, Prost M, Lizard G, Latruffe N. A moderate red wine intake improves blood lipid parameters and erythrocytes membrane fluidity in post myocardial infarct patients. Mol Nutr Food Res. 2011 Oct 31. PubMed PMID: 22038950. IF moy 4.36 

Tili E, Michaille JJ, Wernicke D, Alder H, Costinean S, Volinia S, Croce CM. Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer. Proc Natl Acad Sci U S A. 2011;108:4908-13. IF moy 10

Tili E, Michaille JJ. Resveratrol, MicroRNAs, Inflammation, and Cancer. J Nucleic Acids. 2011;2011:102431. 


 Chamouton J, Hansmannel F, Bonzo JA, Clémencet MC, Chevillard G, Battle M, Martin P, Pineau T, Duncan S, Gonzalez FJ, Latruffe N, Mandard S, Nicolas-Francès V. The Peroxisomal 3-keto-acyl-CoA thiolase B Gene Expression Is under the Dual Control of PPARα and HNF4α in the Liver. PPAR Res. 2010; 2010:352957. Epub 2011 Mar 6. IF moy 2.73

 Dugas B, Charbonnier S, Baarine M, Ragot K, Delmas D, Ménétrier F, Lherminier J, Malvitte L, Khalfaoui T, Bron A, Creuzot-Garcher C, Latruffe N, Lizard G. Caspase-Independent Cell Death Induction, Overproduction of Reactive Oxygen Species, and Enhancement of IL-1β, IL-6, IL-8, MCP-1 and/or VEGF Secretion in Oxysterol-Treated Human Retinal Cells (ARPE-19): Cytoprotective Effects and Prevention of VEGF Secretion by Resveratrol. Eur J Nutr. 2010 49(7):435-446. IF moy. 2.63

Kahn E, Baarine M, Pelloux S, Riedinger JM, Frouin F, Tourneur Y, Lizard G. Iron Nanoparticles Increase 7-Ketocholesterol Induced Cell Death, Inflammation, and Oxidation on Murine Cardiac HL1-NB Cells. Int J Nanomed. 2010; 5: 185-95. IF moy 1.64.

Labenne M, Lizard G, Ferdynus C, Montange T, Iacobelli S, Bonsante F, Gouyon JB. A clinic-biological score for diagnosing early onset neonatal infection in critically ill preterm infants. Pediatric Critical Care Medicine. 2010; 11, (in press, PMID: 20495505). IF moy 2.33

Maillefert JF, Puéchal X, Falgarone G, Lizard G, Ornetti P, Solau E, Legré V, Lioté F, Sibilia J, Morel J, Maynadié M; Réseau Rhumato Study Group. Prediction of response to disease modifying antirheumatic drugs in rheumatoid arthritis. Joint Bone Spine. 2010 (in press, PMID: 20478729) IF moy 1.95

Mazué F, Colin D, Gobbo J, Wegner M, Resfinato A, Spatafora C, Vervandier-Fasseur D, Delmas D, Meunier P, Tringali C, Latruffe N. Structural determinants of resveratrol for cell prolifertion inhibition potency: Experimental and docking studies of new analogs. Eur J Med Chem. 2010; 45: 2972-80. IF moy. 3.11

Meunier-Prest R, Bouyon A, Rampazzi E, Raveau S, Andreoletti P, Cherkaoui-Malki M. Electrochemical probe for the monitoring of DNA-protein interactions. Biosens Bioelectron. 2010; 25: 2598–2602. IF moy. 5.14

Mountassif D, Andreoletti P, Cherkaoui-Malki M, Latruffe N, El Kebbaj, MS. Structural and catalytic properties of the D-3-hydroxybutyrate dehydrogenase from Pseudomonas aeruginosa. 2010. Current Microbiology. 61: 7-12. IF moy 1.43

Tili E, Michaille JJ (°), Alder H, , Volinia S, Delmas D, Latruffe N, Croce C (2010) Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells. Biochem Pharmacol. 2010; 80: 2057-65. IF moy. 4.01 (°) corresponding author

Tili E, Michaille JJ (°), Liu CG, Alder H, Taccioli C, Volinia S, Calin GA, Croce CM. GAM/ZFp/ZNF512B is central to a gene sensor circuitry involving cell-cycle regulators, TGF{beta} effectors, Drosha and microRNAs with opposite oncogenic potentials. Nucleic Acids Res. 2010; 38:7673-7688. IF moy. 7.27 (°) corresponding author

Vluggens A, Andreoletti P, Viswakarma N, Jia Y, Matsumoto K, Kulik W, Khan M, Huang J, Guo D, Yu S, Sarkar J, Singh I, Rao MS, Wanders RJ, Reddy JK and Cherkaoui-Malki M. Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) Null Phenotype by human ACOX1b isoform. Lab Invest. 2010; 90: 696-708. IF moy. 4.13

Tili E, Michaille JJ, Adair B, Alder H, Taccioli C, Delmas D, Latruffe N, Croce CM. Resveratrol contains the inflammatory response to LPS through the up regulation of miR-663, a microRNA targeting AP-1 components. Carcinogenesis. 2010, 31: 1561-1566. IF moy. 5.21


 Akil O, El Kebbaj Z, Latruffe N,  El Kebbaj MSE. D-3 hydroxybutyrate oxidation in mitochondria by D-3-Hydroxybutyrate dehydrogenase in Tetrahymena pyriformis . Afric J Biochem Res. 2009; 3 (3) 29-36.

 Arnauld S, Fidaleo M, Clemencet M-C, Chevillard G, Athias A, Gresti J, Wanders RJA, Latruffe N, Nicolas-Francès V, Mandard S. Modulation of the hepatic fatty acid pool in peroxisomal 3-ketoacyl-CoA Thiolase B in mice exposed to the selective PPARalpha agonist Wy14,643, Biochimie.  2009; 91:  1376-1386. IF moy. 3.16

Andréoletti P, Mouesca JM, Gouet P, Jaquinod M, Capeillère-Blandin C, Jouve HM. Verdoheme formation in Proteus mirabilis catalase. Biochim Biophys Acta. 2009; 1790(8): 741-53. IF moy 2.82

Baarine M. Ragot K, Genin EC, El Hajj H, Trompier D, Andréoletti P, Ghandour S, Menetrier F, Cherkaoui-Malki M, Savary S, Lizard G. Peroxisomal and Mitochondrial Status of Two Murine Oligodendrocytic Cell Lines (158N, 158JP): Potential Models for the Study of Peroxisomal Disorders Associated with Dysmyelination Processes. J Neurochem. 2009; 111: 119-131. IF moy. 4.55

Cabaton N, Dumont C, Severin I, Perdu E, Zalko D, Cherkaoui-Malki M, Chagnon MC. Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line. Toxicology. 2009; 255: 15-24. IF moy 3.08

El Kebbaj Z, Mountassif D, Andreoletti P, Kabine M, Schohn H, Dauça M, Latruffe N, El Kebbaj MSE, Cherkaoui Malki M. Differential regulation of peroxisome proliferator-activated receptor (PPAR alpha 1 and truncated PPAR alpha 2) as an adaptive response to fasting in the control of hepatic peroxisomal fatty acid b-oxidation in the hibernating mammal. Endocrinology.  2009; 150: 1192-1201. IF moy. 5.25

Genin EC, Gondcaille C, Trompier D, Savary S. Induction of the Adrenoleukodystrophy-Related Gene (ABCD2) by thyromimetics J Steroid Biochem Mol Biol. 2009; 116: 37-43.  IF moy. 3.05

Joffre C, Souchier M, Leclere L, Buteau B, Grégoire S, Lizard G, Montange T, Acar N, Bron AM, Creuzot-Garcher CP, Diebold Y, Bretillon L. Branched-chain fatty acids, increased in tears of blepharitis patients, are not toxic for conjunctival cells. Br J Ophthalmol. 2009; 93: 1391-1395. IF moy 2.52

Kahn E, Pelloux S, Baarine M, Khalfaoui T, Ragot K, Frouin F, Riedinger JM, Tourneur Y, Lizard G. Analysis of the Capture and Influence of Nanoparticles on the Cytotoxic Effects of 7-Ketocholesterol on Cardiac Cells: Investigation by Flow Cytometry and by Dynamic and Spectral Imaging Microscopy Associated with Factor Analysis of Medical Image Sequences. Anal Quant Cytol Histol.  2009; 31: 380-394. IF moy 2.94

Khalfaoui T, Mkannez G, Colin D, Imen A, Zbiba W, Errais K, Anane R, Beltaief O, Zhioua R, J BH, Lizard G, Meddeb AO. Immunohistochemical analysis of vascular endothelial growth factor (VEGF) and p53 expression in pterygium from Tunisian patients. Pathol Biol. (Paris). (2009) (in press). IF moy 0.95

Lemaire-Ewing S, Berthier A, Royer MC, Logette E, Corcos L, Bouchot A, Monier S, Prunet C, Raveneau M, Rébé C, Desrumaux C, Lizard G, Néel D. 7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent. Cell Biol Toxicol. 2009; 25(2): 127-39. IF moy 2.1

Lehmann S, Roche S, Allory Y, Barthelaix A, Beaudeux JL, Berger F, Betsou F, Borg J, Dupuy A, Garin J, Quillard M, Lizard G, Peoc'h K, Riviere M, Ducoroy P. Preanalytical guidelines for clinical proteomics investigation of biological fluids. Ann Biol Clin. (Paris). 2009; 67(6): 629-639. IF moy 0.38

Mountassif D, Kabine M, Mounchid K, Mounaji, M, Latruffe N, El Kebbaj MSE. Sensitivity of liver metabolism from jerboa (Jaculus orientalis) to ciprofibrate, a peroxisome proliferator. Mol Med Reports. 2009; 2: 597-602.

Vejux A, Guyot S, Montange T, Riedinger JM, Kahn E, Lizard G. Phospholipidosis  and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis. J Nutr Biochem. 2009; 20: 45-61. IF moy 3.94


 Bernard A, Rigault C, Mazue F, Le Borgne F, Demarquoy J. L-carnitine supplementation and physical exercise restore age-associated decline in some mitochondrial functions in the rat. J Gerontol A-Biol. 2008; 63:1027-1033. IF moy 2.86

 Colin D, Lançon A,  Delmas D, Abrassimow J,  Jannin B,  Lizard G, Kahn E, Latruffe N. Comparative study of the cell uptake and the antiproliferative effects of resveratrol, epsilon-viniferin and their acetates. Biochimie. 2008; 90: 1674-1684. IF moy. 3.16

Colin D, Gimazane A, Lizard G, Izard J-C, Solary E. Latruffe N, Delmas D. Resveratrol analogues compounds-induced early S phase arrest through specific Cdk/cyclin complex which leads to a higher sensitization of human colon cancer cells to 5-FU. Int J Cancer. 2008; 124 (12): 2780-2788. IF moy. 4.65

Hanet N, Lançon A, Heydel JM, Jannin B, Delmas D, Chagnon MC, Cherkaoui Malki M, Latruffe N, Artur Y. Endocrine disruptors affect 17b-estradiol cellular bioavailability and the expression of proteins involved in the hormone metabolism and exretion in HepG2. Steroids. 2008; 73: 1242-1251. IF moy 2.56

Khalfaoui T, Lizard G, Beltaief O, Colin D, Ben Hamida J, Errais K, Ammous I, Zbiba W, Tounsi L, Zhioua R, Anane R, Ouertani-Meddeb A. Immunohistochemical analysis of cellular adhesion molecules (ICAM-1, VCAM-1) and VEGF in fibrovascular membranes of patients with proliferative diabetic retinopathy: Preliminary study. Pathol Biol (Paris). 2008; (in press) IF moy 0.95

Khalfaoui T, Lizard G, Ouertani-Meddeb A. Adhesion molecules (ICAM-1 and VCAM-1) and diabetic retinopathy in type 2 diabetes. J Mol Histol. 2008; 39: 243-9. IF moy 1.85

Le Borgne F, Rigault C, Georges B, Demarquoy J. Nutritional and hormonal control of L-carnitine uptake in myoblastic C2C12 cells. Muscle Nerve. 2008; 38: 912-915. IF moy. 2.73

Leclercq S, Skrzypski J, Courvoisier A, Gondcaille C, Bonnetain F, André A, Chardigny JM, Bellenger S, Bellenger J, Narce M, Savary S. Effect of dietary polyunsaturated fatty acids on the expression of peroxisomal ABC transporters. Biochimie. 2008; 90:1602-1607. IF moy. 3.16

Malvitte L, Montange T, Vejux A, Joffre C, Bron A, Creuzot-Garcher C, Lizard G. Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7beta-hydroxycholesterol. Curr Eye Res. 2008; 33: 769-81. IF moy 1.44

Marel AC, Lizard G, Izard J-C, Latruffe N, Delmas D. Effect of resveratrol derived molecules on the proliferation and the cell cycle progression of human tumoral cells. Mol Nut Fd Res. 2008; 52 (5) 538-548. IF moy. 3.72

Mountassif D, P. Andréoletti, Z. El Kebbaj, A. Moutaouakkil, Cherkaoui-Malki M, Latruffe N & El Kebbaj MSE. A new purification method for characterization of the mitochondrial membrane-bound D-3-hydroxybutyrate dehydrogenase from Jaculus orientalis  BMC Biochem. 2008; 9 (1) : 26.  IF moy 2.4

 Rigault C, Dias JV, Demarquoy J, Le Borgne F. Characteristics of l-carnitine import into heart cells. Biochimie. 2008, 90 : 542-6. IF moy. 3.16

Rigault C, Mazue F, Bernard A, Demarquoy J, Le Borgne F. Changes in L-carnitine content of fish and meat during domestic cooking. Meat Sci. 2008, 78: 331-5. IF moy. 2.74

Rigault C, Bernard A, Georges B, Kandel A, Pfutzner E, Le Borgne F, Demarquoy J. Extracellular ATP increases L-carnitine transport and content in myoblastic C2C12 cells. Pharmacology. 2008; 81(3): 246-250. IF moy. 1.62


 Gueugnon F, C, Gondcaille, Leclercq S, Bellenger J, Bellenger S, Narce M, Pineau T, Bonnetain F, Savary S. Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene (ABCD2) independently of PPARalpha Biochimie. 2007, 89: 1312-1321. IF moy. 3.16

Lançon A, HanetN, Jannin B, Delmas D, Heydel JM, Lizard G, Chagnon MC, Artur Y, Latruffe  N. Resveratrol in human hepatoma HepG2 cells : metabolism and inducibility of detoxifying enzymes. Drug Metab Dispos 2007;  35: 699-703. IF moy. 4.31

Oaxaca-Castillo D, Andréoletti P, Vluggens A, Yu S, Van Veldhoven P, Reddy JK,  Cherkaoui-Malki M. Functional expression and characterization of recombinant human liver acyl-CoA oxidase isoforms 1a and 1b. Biochim Biophys Res Commun. 2007; 360: 314-319. IF moy. 2.82

Rigault C,  Le Borgne F, Georges B, Demarquoy J. Ghrelin reduces hepatic mitochondrial fatty acid oxidation J Endocrinol Invest. 2007; 30 : RC 4-8. IF moy. 2.13

Mountassif D, Kabine M, Mounchid K, Mounaji, Cherkaoui-Malki M, Latruffe N, El Kebbaj MSE. Biochemical and Histological alterations of cellular metabolism from jerboa (Jaculus orientalis) by 2, 4-Dichlorophenoxyacetic acid: Effects  on D-3-hydroxybutyrate dehydrogenase. Pestic Biochem Physiol.   2007; 90: 87-96. IF moy 1.50

Joffre C, Leclerc L, Buteau B, Martine L, Cabaret S, Malvitte L, Acar N, Lizard G, Bron A, Creuzot-Garcher C, Bretillon L Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. Curr Eye Res. 2007; 32: 271-280. IF moy 1.2

Malvitte L, Montange T, Vejux A, Baudouin C, Bron AM, Creuzot-Garcher C,  Lizard G. Brit. J. Ophtalmol. 2007; 91: 29-32. IF moy 2.52

Mountassif D, Kabine M, Latruffe N, El Kebbaj MSE Prehibernation and hibernation effects on the D-3-hydroxybutyrate dehydrogenase of the heavy and light mitochondria from liver jerboa (Jaculus orientalis) and related metabolism. Biochimie. 2007; 89: 1019-1028. IF moy 3.16

Vejux A, Kahn E, Menetrier F, Montange T, Lherminier J, Riedinger JM, Lizard G.  Cytotoxic oxysterols induce caspase-independent myelin figure formation and caspase-dependent polar lipid accumulation Histochem Cell Biol, 2007; 127: 609-624. IF moy 2.39

Véjux A, Lizard G, Tourneur Y, Riedinger JM, Frouin F, Kahn E. Effects of caspâse o,jobotprs (z-VAD-fmk, z-VDVAD-fmk) on Nile red fluorescence pattern in 7-ketocholesterol-treated cells : investigation by flow cytometry and spectral imaging microscopy Cytometry. 2007; 71: 550-562. IF moy 3.21

Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B, Fabbri M, Alder H, Liu CG, Calin GA, Croce CM. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol. 2007; 179: 5082-5089. IF moy 6.16


 Rigault C, Le Borgne F, Demarquoy J. Genomic structure, alternative maturation and tissue expression of the human BBOX1 gene. Biochim Biophys Acta. 2006; 1761: 1469-1481. IF moy. 3.6  

Gueugnon F, Et Taouil J, Lopez TE, GondcailleC, Sequeira-Legrand A, Mooijer PA, Kemp S, Wanders RJA, Savary S. A novel cell model to study the function of the adrenoleukodystrophy-related protein. Biochem Biophys Res Commun. 2006; 341:150-157. IF moy. 2.82

Guichard C, Pedruzzi E, Fay M, Marie JC, Braut-Boucher F, Daniel F, Grodet A, Gougerot-Pocidalo MA, Chastre E, Kotelevets L, Lizard G, Vandewalle A, Driss F, Ogier-Denis E.. Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells. Carcinogenesis. 2006; 27(9): 1812-1827. IF moy 5.21

Prunet C, Petit JM, Ecarnot-Laubriet A, Athias A, Miguet-Alfonsi C, Rohmer JF, Steinmetz E, Néel D, Gambert P, Lizard G. High circulating levels of 7beta- and 7alpha-hydroxycholesterol and presence of apoptotic and oxidative markers in arterial lesions of normocholesterolemic atherosclerotic patients undergoing endarterectomy. Pathol Biol.  (Paris). 2006; 54: 22-32.IF moy 0.95

Prunet C, Montange T, Véjux A, Laubriet A, Rohmer JF, Riedinger JM, Athias A, Lemaire-Ewing S, Néel D, Petit JM, Steinmetz E, Brenot R, Gambert P, Lizard G. Multiplexed flow cytometric analyses of pro- and anti-inflammatory cytokines in the culture media of oxysterol-treated human monocytic cells and in the sera of atherosclerotic patients. Cytometry A. 2006; 69: 359-73. IF moy 3.21

Kahn E, Vejux A, Ménétrier F, Maiza C, Hammann A, Sequeira-Le Grand A, Frouin F, Tourneur Y, Brau F, Riedinger JM, Steinmetz E, Todd-Pokropek A, Lizard G. Analysis of CD36 expression on human monocytic cells and atherosclerotic tissue sections with quantum dots: investigation by flow cytometry and spectral imaging microscopy. Anal Quant Cytol Histol. 2006; 28: 14-26. IF moy 2.94

Kahn E, Ménétrier F, Vejux A, Montange T, Dumas D, Riedinger JM, Frouin F, Tourneur Y, Brau F, Stoltz JF, Lizard G. Flow cytometry and spectral imaging multiphoton microscopy analysis of CD36 expression with quantum dots 605 of untreated and 7-ketocholesterol-treated human monocytic cells. Anal Quant Cytol Histol. 2006; 28:316-330. IF moy 2.94

Mountassif D, Kabine M. Latruffe N EL Kebbaj MSE. Characterization of two D-3-hydroxybutyrate dehydrogenase populations in heavy and light mitochondria from jerboa (Jaculus orientalis) liver. Comp Biochem Physiol  B. 2006; 143: 285-293. IF moy 1.77

Mountassif D, Kanbine M, Manar R, Bourhim N, Zaroual Z, Latruffe N, EL Kebbaj MSE. Physiological, morphological and metabolic changes in Tetrahymena pyriformis for the in vivo cytotoxicity assessement of metallic pollution: Impact on D-beta-hydroxybutyrate dehydrogenase. Ecological Indicators. 2006; 7: 882-894. IF moy 1.14

Girard A, Madani, Boukortt S, Cherkaoui Malki M, Belleville J, Prost J.  Fructose-enriched diet modifies antioxidant status and lipid metabolism in spontaneously hypertensive rats. Nutrition. 2006; 22: 758-766. IF moy 2.56


 Gondcaille C, Deptreter M, Fourcade S, Lecca MR, Leclercq S, Martin P, Pineau T, Cadepond F, El Etr M, Bertrand N, Beley A, Duclos S, De Craemer D, Roels F, Savary S, Bugaut M. Phenylbutyrate up-regulates the Adrenoleukodystrophy-related gene as a non-classical peroxisome proliferator J. Cell. Biol. 2005, 169: 93-104; IF moy 10.12

Legay G, Finot E, Meunier-Prest R, Cherkaoui Malki M, Latruffe N, Dereux AA. Measurement of the DNA Film Thickness in Air and in Liquid Using an Atomic Force Microscope. Biosensors & Bioelectronics 2005, 21: 627-636. IF moy 5.48

Clemencet M-C, Muzio G, Trombetta A, Peters JM, Gonzalez FJ, Canuto RA,  Latruffe N. Differences in cell proliferation in rodent and human hepatic derived  cell lines exposed to ciprofibrate. Cancer Letters 2005, 222 : 217-26. IF moy 3.54

Vejux A, Kahn E, Dumas D, Bessede G, Menetrier F, Athias A, Riedinger JM,  Frouin F, Stoltz JF, Ogier-Denis E, Todd-Pokropek A, Lizard G. 7-ketocholesterol  favors lipid accumulation and colocalize with Nile Red positive cytoplasmic structures formed during  7-ketocholesterol-induced apoptosis: analysis by flow cytometry, FRET biphoton spectral imaging  microscopy, and subcellular fractionation. Cytometry, 2005, 64A: 87-100. IF 3.29

Prunet C, Lemaire-Ewing S, Menetrier F, Neel D, Lizard G. Activation of caspase-3-dependent  and -independent pathways during 7-ketocholesterol- and 7-hydroxycholesterol-Induced cell death: morphological and biochemical study. J Biochem Mol Toxicol. 2005 19:311-26. IF moy 1.84

Lemaire-Ewing S, Prunet C, Montange T, Vejux A, Berthier A, Bessede G, Corcos L, Gambert P, Neel D, Lizard G. Comparison of the cytotoxic, pro-oxidant and pro- inflammatory characteristics of different oxysterols. Cell Biol Toxicol. 2005, 21: 97-114. IF moy  1.83

Kahn E, Lizard G, Dumas D, Frouin F, Menetrier F, Stolz JF, Todd-Pokropek A. Analysis of fluorescent MRI contrast agent behavior in the liver and thoracic aorta of mice. Analyt Quant Cytol Histol, 2005, 26(4):233-8. IF moy 2.94

Zandbergen F, Mandard S, Escher P, Tan N S, Patsouris D, Jatkoe T, Rojas-Caro S, Madore S, Wahli W, Tafuri S, Müller M, Kersten S. The G0/G1 switch gene 2 is a novel PPAR target gene, Biochem J. 2005, 392(Pt 2):313-24. IF moy  4.36

Michaille J-J, Tilli E, Calin G, Garin J, Louwagie M, Croce CM. Cloning and characterization of chicken cDNAs encoding different isoforms of a putative zinc fnger developmental transcription factor, Biochimie, 2005, 87:939-49. IF moy 3.48

Pedruzzi E, Guichard C, Ollivier V, Driss F, Fay M, Prunet C, Marie JC,  Pouzet C, Samadi M, Elbim C, O’Dowd Y, Bens M, Vandewalle A, Gougerot- Pocidalo MA, Lizard G, Ogier-Denis E. NAD(P)H oxidase Nox-4 mediates 7- ketocholesterol-induced endoplasmic stress and apoptosis in human aortic smooth muscle cells. Mol  Cell Biol, 2005, 24 : 10703-17. IF moy 6.36

Genolet R, Kersten S, Braissant O, Mandard S, Tan NS, Bucherr P, Desvergne B, Michalik L, Wahli W. Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha. J Biol Chem. 2005, 280: 24143 - 52, IF moy 5.44

Berthier A, Lemaire-Ewing S, Prunet C, Montange T, Vejux A, Pais de Barros JP, Monier S, Gambert P, Lizard G, Neel D. D. 7-ketocholesterol induced apoptosis. FEBS  J (ex Eur J Biochem), 2005, 272: 3093-3104. IF moy 3.27

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