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Laboratoire Bio-PeroxIL - EA 7270




  • Di Cara, F, Savary S, Kovacs, W., Kim, P., Rachubinski, R.A. The peroxisome: an up-and-coming organelle in immunometabolism. Trends Cell Biol. 33(1):70-86 (2023).


  • Salvi J, Andreoletti P, Audinat E, Balland E, Ben Fradj S, Cherkaoui-Malki M, Heurtaux T, Lienard F, Nedelec E, Rovere N, Savary S, Vejux A, Trompier D and Benani A. Microgliosis: a double-edged sword in the control of food intake. The FEBS journal
  • El Midaoui A, Ghzaiel I, Vervandier-Fasseur D, Ksila M, Zarrouk A, Nury T, Khallouki F, El Hessni A, Ibrahimi SO, Latruffe N, Couture R, Kharoubi O, Brahmi F, Hammami S, Masmoudi-Kouki O, Hammami M, Ghrairi T, Vejux A, Lizard G. Saffron (Crocus sativus L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases. Nutrients. 2022 Jan 29;14(3):597. doi: 10.3390/nu14030597. PMID: 35276955; PMCID: PMC8839854.
  • Sahakyan G, Vejux A, Sahakyan N. The Role of Oxidative Stress-Mediated Inflammation in the Development of T2DM-Induced Diabetic Nephropathy: Possible Preventive Action of Tannins and Other Oligomeric Polyphenols. Molecules. 2022 Dec 18;27(24):9035.
  • Rezig L, Ghzaiel I, Ksila M, Yammine A, Nury T, Zarrouk A, Samadi M, Chouaibi M, Vejux A, Lizard G. Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity: Application to age-related diseases and civilization diseases. Steroids. 2022 Nov;187:109093.
  • Brahmi F, Vejux A, Ghzaiel I, Ksila M, Zarrouk A, Ghrairi T, Essadek S, Mandard S, Leoni V, Poli G, Vervandier-Fasseur D, Kharoubi O, El Midaoui A, Atanasov AG, Meziane S, Latruffe N, Nasser B, Bouhaouala-Zahar B, Masmoudi-Kouki O, Madani K, Boulekbache-Makhlouf L, Lizard G. Role of Diet and Nutrients in SARS-CoV-2 Infection: Incidence on Oxidative Stress, Inflammatory Status and Viral Production. Nutrients. 2022 May 25;14(11):2194. doi: 10.3390/nu14112194. PMID: 35683996; PMCID: PMC9182601.
  • Essadek S, Bouchab H, El Kebbaj R, Gondcaille C, El Kamouni S, Savary S, Vamecq J, Essamadi A, Cherkaoui-Malki M, Nasser B, Andreoletti P. Effects of a Short-Term Lipopolysaccharides Challenge on Mouse Brain and Liver Peroxisomal Antioxidant and β-oxidative Functions: Protective Action of Argan Oil. Pharmaceuticals (Basel). 2022 Apr 12;15(4):465. doi: 10.3390/ph15040465. PMID: 35455460 Free PMC article.



  • Atanasov AG, Zotchev SB, Dirsch VM; International Natural Product Sciences Taskforce, Supuran CT, Lizard G et al. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov. 2021 Mar;20(3):200-216. doi: 10.1038/s41573-020-00114-z. Epub 2021 Jan 28. PMID: 33510482; PMCID: PMC7841765.Revue
  • Biasi F, Leoni V, Gamba P, Sassi K, Lizard G, Poli G. Role of 27-hydroxycholesterol and its metabolism in cancer progression: Human studies. Biochem Pharmacol. 2022 Feb;196:114618. doi: 10.1016/j.bcp.2021.114618. Epub 2021 May 21. PMID: 34023292.
  • Charrière K, Ghzaiel I, Lizard G, Vejux A. Involvement of Microglia in Neurodegenerative Diseases: Beneficial Effects of Docosahexahenoic Acid (DHA) Supplied by Food or Combined with Nanoparticles. Int J Mol Sci. 2021 Sep 30;22(19):10639. doi: 10.3390/ijms221910639. PMID: 34638979; PMCID: PMC8508587.
  • de Freitas FA, Levy D, Zarrouk A, Lizard G, Bydlowski SP. Impact of Oxysterols on Cell Death, Proliferation, and Differentiation Induction: Current Status. Cells. 2021 Sep 3;10(9):2301. doi: 10.3390/cells10092301. PMID: 34571949; PMCID: PMC8468221. Revue
  • Ghzaiel I, Sassi K, Zarrouk A, Nury T, Ksila M, Leoni V, Bouhaouala-Zahar B, Hammami S, Hammami M, Mackrill JJ, Samadi M, Ghrairi T, Vejux A, Lizard G. 7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19 J Steroid Biochem Mol Biol. 2021 Sep; 212: 105939. Published online 2021 Jun 9. doi: 10.1016/j.jsbmb.2021.105939 - PMCID: PMC8188774
  • Klionsky DJ, Abdel-Aziz AK, Abdelfatah S,… Lizard G, Zarrouk A, ... Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751; PMCID: PMC7996087. Revue
  • Nury T, Yammine A, Ghzaiel I, Sassi K, Zarrouk A, Brahmi F, Samadi M, Rup- Jacques S, Vervandier-Fasseur D, Pais de Barros JP, Bergas V, Ghosh S, Majeed M, Pande A, Atanasov A, Hammami S, Hammami M, Mackrill J, Nasser B, Andreoletti P, Cherkaoui-Malki M, Vejux A, Lizard G. Attenuation of 7-ketocholesterol- and 7ß-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases. Ageing Res Rev. 2021 Jul;68:101324. doi: 10.1016/j.arr.2021.101324. Epub 2021 Mar 24. PMID: 33774195. Revue
  • Nury T, Zarrouk A, Yammine A, Mackrill JJ, Vejux A, Lizard G. Oxiapoptophagy: A type of cell death induced by some oxysterols. Br J Pharmacol. 2021 Aug;178(16):3115-3123. doi: 10.1111/bph.15173. Epub 2020 Jul 23. PMID: 32579703. Revue
  • Vejux A, Ghzaiel I, Nury T, Schneider V, Charrière K, Sghaier R, Zarrouk A, Leoni V, Moreau T, Lizard G. Oxysterols and multiple sclerosis: Physiopathology, evolutive biomarkers and therapeutic strategy. J Steroid Biochem Mol Biol. 2021 Jun;210:105870. doi: 10.1016/j.jsbmb.2021.105870. Epub 2021 Mar 5. PMID: 33684483.Revue
  • Yammine A, Namsi A, Vervandier-Fasseur D, Mackrill JJ, Lizard G, Latruffe N. Polyphenols of the Mediterranean Diet and Their Metabolites in the Prevention of Colorectal Cancer. Molecules. 2021 Jun 8;26(12):3483. doi: 10.3390/molecules26123483. PMID: 34201125; PMCID: PMC8227701. Revue


  • Delmas D, Xiao J, Vejux A, Aires V. Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity. Molecules. 2020; 25(9):2009. Published 2020 Apr 25. doi:10.3390/molecules25092009
  • Lizard G, Latruffe N, Vervandier-Fasseur D. Aza- and Azo-Stilbenes: Bio-Isosteric Analogs of Resveratrol. Molecules. 2020 Jan 30;25(3):605. doi: 10.3390/molecules25030605. PMID: 32019195; PMCID: PMC7037676.
  • Masmoudi-Kouki O, Namsi A, Hamdi Y, Bahdoudi S, Ghouili I, Chuquet J, Leprince J, Lefranc B, Ghrairi T, Tonon MC, Lizard G, Vaudry D. Cytoprotective and Neurotrophic Effects of Octadecaneuropeptide (ODN) in <i>in vitro</i> and <i>in vivo</i> Models of Neurodegenerative Diseases. Front Endocrinol (Lausanne). 2020 Nov 4;11:566026. doi: 10.3389/fendo.2020.566026. PMID:33250858; PMCID: PMC7672186.
  • Nury T, Lizard G, Vejux A. Lipids Nutrients in Parkinson and Alzheimer's Diseases: Cell Death and Cytoprotection. Int J Mol Sci. 2020;21(7):2501. Published 2020 Apr 3. doi:10.3390/ijms21072501
  • Nury T, Zarrouk A, Yammine A, Mackrill JJ, Vejux A, Lizard G. Oxiapoptophagy: a type of cell death induced by some oxysterols [published online ahead of print, 2020 Jun 24]. Br J Pharmacol. 2020;10.1111/bph.15173. doi:10.1111/bph.15173 co-corresponding author
  • Vejux A, Abed-Vieillard D, Hajji K, Zarrouk A, Mackrill JJ, Ghosh S, Nury T, Yammine A, Zaibi M, Mihoubi W, Bouchab H, Nasser B, Grosjean Y, Lizard G. 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochem Pharmacol. 2020 Mar;173:113648. doi: 10.1016/j.bcp.2019.113648. Epub 2019 Oct 3. PMID: 31586589.
  • Wu A, Wójtowicz K, Savary S, Hamon Y, Trombik T Would ABC transporters tune the plasma membrane organization? Cell Mol Biol Lett 25(1): 37 (2020).



  • Di Cara F, Andreoletti P, Trompier D, Vejux A, Bülow MH, Sellin J, Lizard G, Cherkaoui-Malki M, Savary S. Peroxisomes in Immune Response and Inflammation. Int J Mol Sci. 2019 Aug 8;20(16).
  • Michaille JJ, Awad H, Fortman EC , Efanov AA, Tili E. miR-155 expression in antitumor immunity: The higher the better? Genes Chromosomes Cancer. 2019 Apr;58(4):208-218. doi: 10.1002/gcc.22698. PMID: 30382602 DOI: 10.1002/gcc.22698
  • Savary S; Peroxysome et maladies neurologiques. La lettre du neurologue 23(5):164-170 (2019)


  • Bezine M, Namsi A, Sghaier R, Ben Khalifa R, Hamdouni H, Brahmi F, Badreddine I, Mihoubi W, Nury T, Vejux A, Zarrouk A, de Sèze J, Moreau T, Nasser B, Lizard G. The effect of oxysterols on nerve impulses.Biochimie. 2018 Oct;153:46-51. doi: 10.1016/j.biochi.2018.04.013. Epub 2018 Apr 21. Review - PMID: 29684511
  • Brahmi F, Vejux A, Sghaier R, Zarrouk A, Nury T, Meddeb W, Rezig L, Namsi A, Sassi K, Yammine A, Badreddine I, Vervandier-Fasseur D, Madani K, Boulekbache-Makhlouf L, Nasser B, Lizard G. Prevention of 7-ketocholesterol-induced side effects by natural compounds.Crit Rev Food Sci Nutr. 2018 Oct 16:1-20. doi: 10.1080/10408398.2018.1491828. [Epub ahead of print] - PMID: 29993272
  • Michaille JJ, Piurowski V, Rigot B, Kelani H, Fortman EC, Tili E. MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol. Medicines (Basel). 2018 Jul 9;5(3):74. doi: 10.3390/medicines5030074. PMID: 29987196 Free PMC article. Review.
  • Nuovo G, Tili E, Awad H, Michaille JJ. Roles of miR-155 microRNA in dementia associated with Down's syndrome. Med Sci (Paris). 2018 Nov;34(11):922-924. doi: 10.1051/medsci/2018231. Epub 2018 Dec 10. PMID: 30526830 Free article. French. No abstract available.
  • Vejux A, Namsi A, Nury T, Moreau T, Lizard G. Biomarkers of Amyotrophic Lateral Sclerosis: Current Status and Interest of Oxysterols and Phytosterols. Front Mol Neurosci. 2018 Jan 31;11:12. doi: 10.3389/fnmol.2018.00012. eCollection 2018. Review. - PMID: 29445325


  • Zarrouk A, Debbabi M, Bezine M, Karym EM, Badreddine A, Rouaud O, Moreau T, Cherkaoui-Malki M, El Ayeb M, Nasser B, Hammami M, Lizard G. Lipid Biomarkers in Alzheimer's Disease. Curr Alzheimer Res. 2017 ; 14. PMID: 28474568.
  • Debbabi M, Nury T, Helali I, Karym EM, Geillon F, Gondcaille C, Trompier D, Najid A, Terreau S, Bezine M, Zarrouk A, Vejux A, Andreoletti P, Cherkaoui-Malki M, Savary S, Lizard G. Flow Cytometric Analysis of the Expression Pattern of Peroxisomal Proteins, Abcd1, Abcd2, and Abcd3 in BV-2 Murine Microglial Cells. Methods Mol Biol. 2017; 1595:257-265.
  • Tili E, Michaille JJ, Piurowski V, Rigot B, Croce CM. MicroRNAs in intestinal barrier function, inflammatory bowel disease and related cancers-their effects and therapeutic potentials . Curr Opin Pharmacol. 2017 Dec;37:142-150. doi: 10.1016/j.coph.2017.10.010. Epub 2017 Nov 15. PMID: 29154194 PMCID: PMC5938753 DOI: 10.1016/j.coph.2017.10.010 Free PMC article


  • Lizard G, Zarrouk A, Moreau T. Implication des lipides dans les maladies neurodégénératives : aspects biologiques et cliniques. La Lettre du Neurologue, N°6, juin 2015.


  • Demarquoy, J., and Borgne, F.L. Biosynthesis, metabolism and function of protectins and resolvins. Clinical Lipidology 9(6): 683-693, (2014).
  • El-Mostafa, K., El Kharrassi, Y., Badreddine, A., Andreoletti, P., Vamecq, J., El Kebbaj, M.S., Latruffe, N., Lizard, G., Nasser, B., and Cherkaoui-Malki, M. Nopal cactus (Opuntia ficus-indica) as a source of bioactive compounds for nutrition, health and disease. Molecules 19(9): 14879-14901, (2014).
  • Latruffe, N., Menzel, M., Delmas, D., Buchet, R., and Lancon, A. Compared binding properties between resveratrol and other polyphenols to plasmatic albumin: consequences for the health protecting effect of dietary plant microcomponents. Molecules 19(11): 17066-17077, (2014).
  • Trompier, D., Gondcaille, C., Lizard, G., and Savary, S. Regulation of the adrenoleukodystrophy-related gene (ABCD2): focus on oxysterols and LXR antagonists. Biochem Biophys Res Commun 446(3): 651-655, (2014).
  • Trompier, D., Vejux, A., Zarrouk, A., Gondcaille, C., Geillon, F., Nury, T., Savary, S., and Lizard, G. Brain peroxisomes. Biochimie 98: 102-110, (2014).
  • Vamecq, J., Cherkaoui-Malki, M., Andreoletti, P., and Latruffe, N. The human peroxisome in health and disease: the story of an oddity becoming a vital organelle. Biochimie 98: 4-15, (2014).
  • Zarrouk, A., Vejux, A., Mackrill, J., O'Callaghan, Y., Hammami, M., O'Brien, N., and Lizard, G. Involvement of oxysterols in age-related diseases and ageing processes. Ageing Res Rev 18: 148-162, (2014).



  • Demarquoy, J. Meat adulteration: the use of PCR. Meat Sci 94(2): 164, (2013).
  • Latruffe, N. A brief remembrance of Professor Serge Renaud, for the twentieth year celebration of his discovery of the French paradox. J Wine Res 24(2): 167-168, (2013).
  • Latruffe, N., and Rifler, J.P. Bioactive polyphenols from grapes and wine emphasized with resveratrol. Curr Pharm Des 19(34): 6053-6063, (2013).
  • Tili, E., Michaille, J.J., and Croce, C.M. MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer. Immunol Rev 253(1): 167-184, (2013).



  • Cherkaoui-Malki, M., Surapureddi, S., El-Hajj, H.I., Vamecq, J., and Andreoletti, P. Hepatic steatosis and peroxisomal fatty acid beta-oxidation. Curr Drug Metab 13(10): 1412-1421, (2012).
  • Demarquoy, J., Rigault, C., and Le Borgne, F. L-carnitine. Handbook of Analysis of Active Compounds in Functional Foods: 87-104, (2012).
  • Geillon, F., Trompier, D., Gondcaille, C., Lizard, G., and Savary, S. [Peroxisomal ABC transporters and X-linked adrenoleukodystrophy]. Med Sci (Paris) 28(12): 1087-1094, (2012).
  • Lançon, A., Lizard, G., and Latruffe, N. The in vitro anti‐inflammatory and anti‐angiogenic potential of a new resveratrol‐based formula (Resvega). Acta Ophthalmologica 90(s249): 0 (2012).
  • Latruffe, N. Une consommation modérée de vin rouge améliore les paramètres sanguins chez des patients post-opérés d'un infarctus du myocarde. Revue des oenologues et des techniques vitivinicoles et oenologicques: magazine trimestriel d'information professionnelle 39(144): 54-56, (2012).
  • Le Borgne, F., and Demarquoy, J. Interaction between peroxisomes and mitochondria in fatty acid metabolism. Open Journal of Molecular and Integrative Physiology 2: 27-33, (2012).
  • Lizard, G., Rouaud, O., Demarquoy, J., Cherkaoui-Malki, M., and Iuliano, L. Potential roles of peroxisomes in Alzheimer's disease and in dementia of the Alzheimer's type. J Alzheimers Dis 29(2): 241-254, (2012).
  • Savary, S., Trompier, D., Andreoletti, P., Le Borgne, F., Demarquoy, J., and Lizard, G. Fatty acids - induced lipotoxicity and inflammation. Curr Drug Metab 13(10): 1358-1370, (2012).
  • Vamecq, J., Dessein, A.F., Fontaine, M., Briand, G., Porchet, N., Latruffe, N., Andreolotti, P., and Cherkaoui-Malki, M. Mitochondrial dysfunction and lipid homeostasis. Curr Drug Metab 13(10): 1388-1400, (2012).


  • Delmas, D., Solary, E., and Latruffe, N. Resveratrol, a phytochemical inducer of multiple cell death pathways: apoptosis, autophagy and mitotic catastrophe. Curr Med Chem 18(8): 1100-1121, (2011).
  • Latruffe, N. Resveratrol acts by modulating miRNAs. Med Sci (Paris) 27(1): 31-33, (2011).
  • Tili, E., and Michaille, J.J. Resveratrol, MicroRNAs, Inflammation, and Cancer. J Nucleic Acids 2011: 102431, (2011).
  • Vejux, A., Samadi, M., and Lizard, G. Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. J Ophthalmol 2011: 471947, (2011).


  • Latruffe, N. La signalisation cellulaire anti-inflammatoire et anticancéreuse du resvératrol passe par la modulation de microARN. Regard sur la biochimie(oct): 9-10, (2010).



  • Betsou F, Beaudeux JL, Berthelaix A, Borg J, Dupuy A, Lizard G, Peoc'h K, Quillard M, Lehmann S. Standard protocol for evaluating the impact of preanalytical variables on peptidic and proteic analytes and standard coding of preanalytical procedures. Ann Biol Clin. (Paris). 2009; 67(6): 641-649. IF moy 0.38

  • Elbim C, Lizard G. Flow cytometric investigation of neutrophil oxidative burst and apoptosis in physiological and pathological situations. (review) Cytometry A. 2009; 75(6):475-481. IF moy 3.21

  • Lehmann S, Dupuy A, Beaudeux JL, Lizard G. Multiplexed analysis for identification and evaluation of novel biomarkers in biological fluids, tissue and cell extracts. Ann Biol Clin. (Paris). 2009; 67 (4): 381-393. IF moy 0.36

  • Vejux A, Lizard G. Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis. Mol Aspects Med. 2009 Jun;30:153-70.



  • Vejux A, Malvitte L, Lizard G. Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis. Braz J Med Biol Res. 2008; 41: 545-456. IF moy 1.215



  • Tili E, Michaille JJ, Gandhi V, Plunkett W, Sampath D, Calin GA. miRNAs and their potential for use against cancer and other diseases. Future Oncol. 2007; 3: 521-537.



  • Delmas D, Jannin B, Latruffe N  Resveratrol: preventing properties against vascular alterations and ageing. Mol Nut Food Res, 2005, 49: 377-95 IF moy  4.24 (review)

  • Montange T, Vejux A, Labenne M, Poncelet P, Gouyon JB, Lizard G. Cytométrie en flux, microbilles et analyses biomoléculaires multiplexées. Immunoanalyse & Biologie Spécialisée, 2005, 20 : 2-10. (review)

  • Bardon S, Benelli C, Bernard-Gallon D, Blottiere H, Demarquoy J, Duee PH, Forest C. Dietary fatty acids and cancer: potential cellular and molecular mechanisms. Bull Cancer, 2005, 92: 697-707. (review)

  • Mandard S, Kersten S. Regulation of lipogenic genes in obesity. In: Nutritional Genomics: Nutrients, Genes and Genetic Variation in Health and Disease. 2005. Wiley-VCH (review)

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