ENOR 2012
- Publication : jeudi 6 septembre 2012
European Network on Oxysterols Research
2nd ENOR symposium
Oxysterols and related sterols in Chemistry, Biology and Medicine.
Dijon 20-21 September, 2012
Organizing Committee
Anne Athias, Olivier Berdeaux, Lionel Bretillon, Luigi Iuliano, Gérard Lizard,
Jean-Paul Pais de Barros, Anne Vejux
Scientific Committee
Lionel Bretillon (France), Ulf Diczfalusy (Sweden), William J Griffiths (UK), Hervé Guillou (France), Luigi Iuliano (Italy), Valerio Leoni (Italy), Gérard Lizard (France), Jean-Marc Lobacarro (France), Dieter Lütjohann (Germany),David Masson (France), John Mackrill (Ireland), Steve Meaney (Ireland), Vesa Olkkonen (Finland), Marc Poirot (France), Guiseppe Poli (Italy), Maria Teresa Rodriguez Estrada (Italy), Jacob Vaya (Israel), Oliver Weingartner (Germany), Jogchum Plat (The Netherlands), Klaus Seuwen (Switzerland), Maria Luisa Sa e Melo (Portugal), Nora O’Brien (Ireland), Guadalupe Garcia-Llatas (Spain)
PROGRAM
September 20th, 2012
9:00-9:10 Opening of the Symposium: Luigi IULIANO / Gérard LIZARD
9:10-9:30 Welcome: Michel NARCE, Dean of “Faculté des Sciences de la Vie, Terre et Environnement”
9:30-10:30 Opening lecture : William J GRIFFITHS, Swansea University, UK “Methods for oxysterol analysis: past, present and future”
10:30-11:00 Coffee break
Session 1 Analytical clues in oxysterol and phytosterol research (chairman: WJ GRIFFITHS)
11:00-11:20 Silke MATYSIK, University Hospital of Regensburg, Germany “Distribution of oxysterols, plant sterols and cholesterol precursors in lipoprotein fractions”
11:20-11:40 Steven Ray WILSON, University of Oslo, Norway “Studying the role of oxysterols in hedgehog signaling using highly automated AFFL-SPE-LC-MS methodology”
11:40-12:00 Sabine BAUMGARTNER, Maastricht University, The Netherlands “Oxyphytosterol formation in humans: how to identify high versus low oxidizers”
12:00-13:00 Poster session (Chairman: H. GUILLOU) – (5 minutes oral presentation per poster)
13:00-14:00 Lunch (cafeteria Montmuzard)
Session 2 Oxysterol receptors and enzymes (chairman: JM LOBACCARO)
14:00-14:20 Charbel MASSAD, Université Paris-Descartes, France “Opposite effect of LXR on myelination process in the central and peripheral nervous systems and interplay with Wnt pathway”
14:20-14:40 Marion WEBER-BOYAT, Minerva Foundation Institute for Medical Research, Helsinki, Finland “Visualization of ORP-VAP complexes at putative membrane contact sites: novel clues to oxysterol-binding protein function”
14:40-15:00 Lionel BRETILLON, INRA - CNRS, UMR6265 Centre des Sciences du Goût et de l'Alimentation, Dijon, France “When experimental data meet the clinics: evidence that CYP46A1 is specific to retinal neurons and related pathologies”
15:00-15:20 Ulf DICZFALUSY, Karolinska Institutet, Stockholm, Sweden “4β-hydroxycholesterol as a marker for CYP3A4/5 induction”
15:20-15:40 Richard LATHE, State University of Pushchino, Russia “Steroid symmetry”
15:40-16:00 Ingemar BJORKHEM, Karolinska Institutet, Stockholm, Sweden & Hadassah Hebrew University, Israel “Is 27-hydroxycholesterol of importance for regulation of cholesterol homeostasis in brain and liver? Lessons from the CYP27A1 transgenic mouse”
16:00-16:20 Coffee break
Session 3 Oxysterols and inflammation (chairwoman: NM O’BRIEN)
16:20:16:40 Andreas W. SAILER, Novartis Institutes for BioMedical Research, Basel, Switzerland “Oxysterols direct immune cell migration via EBI2”
16:40:17:00 Gabriella LEONARDUZZI, University of Turin, Italy “Plaque oxysterols induce imbalanced up-regulation of MMP-9 in macrophagic cells contributing to plaque instability”
17:00-17:20 Peter GHAZAL, University of Edinburgh, UK “Coupling of 25-hydroxycholesterol to the interferon antiviral response”
Session 4 Oxysterols and nervous system (chairman: I. BJORKHEM)
17:20-17:40 Valerio LEONI, IRCCS Neurology Institute ‘Carlo Besta’, Milan, Italy “Oxysterols and cholesterol metabolism in neurodegeneration. Evidence for anabolic impairment”
17:40-18:00 Dieter LUTJOHANN, University of Bonn, Germany “Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer’s Disease”
20:00 Social Event ; Gala dinner : Cellier de Clairvaux, Dijon, sponsored by the City of Dijon.
September 21st, 2012
Session 5 Biological activities of oxysterols and phytosterols (Chairwoman: G. LEONARDUZZI)
9:00 - 9:20 Nora M. O’BRIEN, University College Cork, Ireland “Oxidized derivatives of campesterol and dihydrobrassicasterol: cytotoxic and apoptotic potential in cell culture systems”
9:20 - 9:40 Laia ALEMANY, University of Valencia, Spain “7-ketostigmasterol protects against 7-ketocholesterol cytotoxicity but induces inflammation to intestinal epithelial cells”
9:40-10:00 Folke SITBON, Swedish University of Agricultural Sciences, Sweden “Oxysterol metabolism in plants”
10:00-10:40 Coffee break
10:40-11:00 M. Manuel CRUZ SILVA, University of Coimbra, Portugal “Oxysterol glycosylation: looking for a better cytotoxic profile”
11:00-11:20 Patrice RAT, Elodie OLIVIER, Université Paris Descartes, France “Oxysterols induce cell death on human retinal pigment epithelial cells with P2X7 cell death receptor activation”
11:20-11:40 Gérard LIZARD, EA7270 / Université de Bourgogne, Dijon, France “Absence of correlation between oxysterol accumulation in lipid rafts, Calcium rise and induction of GSK3-dependent apoptosis in 158N murine oligodendrocytes”
11:40-12:00 Ruth ANDREW, University of Edinburgh, UK “Imaging neutral steroids in tissues by MALDI-FTICR”
12:00-12:45 General Assembly - Round Table (ENOR present and future ENOR’s activities)
12:45-14:00 Lunch (cafeteria Montmuzard)
Session 6 Oxysterols and Cancer (Chairwoman: I VANDENBROUCKE)
14:00-14:20 Jean-Marc LOBACCARO, Université Blaise Pascal, CNRS UMR 6293, GRed / Inserm UMR 1103, GReD, Centre en Nutrition Humaine d’Auvergne, Clermont-Ferrand/Aubière, France “Cholesterol and prostate cancer: the dark side of the life”
14:20-14:40 Norbert BAKALARA, ENS de Chimie de Montpellier, France“7beta-hydroxycholesterol-induced energy stress leads to sequential opposing signaling responses and to death of C6 glioblastoma cells”
14:40-15:00 Marc POIROT, UMR 1037 Inserm / University Toulouse III, France “Importance of the liver-X-receptor-β and cholesterol-5,6-epoxide metabolites in the induction by tamoxifen of triglyceride biosynthesis and cytotoxicity in breast cancer cells”
15:00-15:20 Sérgio P. BYDLOWSKI, University of Sao Paulo, Brazil “In vitro toxicity of cholesterol, 7-ketocholesterol and Cholesterol-3β,5α,6β-triol in different hematological cancer cell lines”
15:20-15:30 Coffee break
Session 7 Oxysterols in cardiovascular and metabolic diseases (Chairman: U. DICZFALUSY)
15:30-15:50 Luigi IULIANO, Sapienza University of Rome, Italy “Oxysterols and lipid metabolism in obesity and metabolic syndrome”
15:50-16:10 M. BAPTISSART, Université Blaise Pascal, CNRS UMR 6293, GRed, Clermont-Ferrand/Aubière, France “Bile acid : a molecular link between liver and testis functions”
16:10-16:30 Gerd SCHMITZ, University Hospital of Regensburg, Germany “Sterol precursors, oxysterols and steroid hormones in platelets and platelet extracellular vesicles in vascular and metabolic diseases”
16:30-16:50 David MASSON, INSERM 866 / Université de Bourgogne, Dijon, France “Differential impact of oxysterol receptors LXR alpha and LXR beta on the regulation of cholesterol efflux in primary human macrophages”
16:50-17:10 Jacob VAYA, Migal – Galilee Technology Center and Tel Hai College, Israel “The mutual effects between the human carotid plaque constituents and the blood components”
17:10-17:30 Closing remarks
Suivez-nous : 
